Rub/Rob Kidney Flashcards Preview

Pathology > Rub/Rob Kidney > Flashcards

Flashcards in Rub/Rob Kidney Deck (29):

Rub 4: Most ectopic kidneys are located along

the pathway of renal migration during fetal development and are caudal to their normal lumbar position; think remaining in the pelvis


Rub 8: Neoplastic plasma cells secrete a

homogenous immunoglobulin chain which can be detected in serum or urine by electrophoresis. Amyloid nephropathy caused by deposition of secreted lambda or kappa light chains in the glomerular BMs and mesangial matrix


Rub 9: Amyloidosis is a well-known complication of chronic inflamm disorders, like

chronic suppurative bronchiectasis, RA, or osteomyelitis; these conditions stimulate the production of amyloid from the serum amyloid A protein


Rub 23: Focal proliferative glomerulonephritis typically presents with

pathologic changes in some glomeruli, whereas others remain normal. This group of diseases includes lupus nephritis, nephritis that accompanies several vasculitides, H-S purpura, and several other disorders. Also includes Berger disease (has mesangial deposits of IgA and mesangial cell prolif)!!!


Rub 24: Acute postinfectious glomerulonephritis features

1. Main features are subepi dense deposits shaped like "humps"
2. Also could have mesangial and subendo deposits


Rub 30: Crescentic glomerulonephritis the morphologic equivalent of

ARF, which could develop in rapidly progressive glomerulonephritis of Goodpasture syndrome


Rub 38: Glucosuria of diabetes predisposes to

acute pyelonephritis by providing a rich medium for bacterial growth; NECROSIS of the PAPILLARY tips could occur in severe cases


Rub 42: Bilateral renal cortical necrosis is a syndrome characterized by

massive tubular necrosis involving large portions of the cortex of both kidneys; massive bilateral renal cortical necrosis typically occurs in the setting of hypovolemia and endotoxic shock


Rub 45: Hypertensive nephroscelrosis (benign nephrosclerosis) leads to

obliteration of glomeruli and could lead to end-stage kidney disease


Rub 49: HUS features

microangiopathic hemolytic anemia and acute renal failure with little or no evidence for significant vascular disease outside the kidneys; think Shiga toxin-producing E coli


Rub 51: RCC is the most

common cancer of the kidney; spreads most frequently to the lung and bones


Rub 54: Neuroblastoma can present as

an abdo mass in children that SECRETES catecholamines and causes elevation of vanillylmandelic acid in the urine


Rub 55: RCC's originate from

renal tubules or ductal epi cells; tumor composed of cuboidal cells that form either tubules or solid nests


Rob 3: Multiple myeloma has the following symptoms:

1. Large amount of serum globulin
2. back pain from lytic lesions
3. Immunosuppression with recurrent infections
4. amyloid deposition enlarging the kidneys


Rob 5: Carcinoma of the urethra is

uncommon, and tends to occur in older women and is locally aggressive


Rob 7: IgA nephropathy can explain the presence of

recurrent hematuria in a young adult; nephrotic syndrome is NOT present, and mesangial IgA deposition is characteristic; think upper respiratory infection and celiac


Rob 10: RCC can potentially secrete

EPO, giving rise to polycythemia


Rob 12: Drug-induced interstitial nephritis can be caused by

sulfonamides, penicillins, cephalosporins, fluoroquinolone antibiotics ciprofloxacin and norfloxacin, and antiTB drugs isoniazid and rifampin; maybe thiazides and loop diuretics, cimetidine, ranitidine, omeprazole, NSAIDs


Rob 18: Ischemic acute tubular necrosis often accompanied by

rupture of the basement membrane (tubulorrhexis)


Rob 19: Painless hematuria in an older adult suggests

renal neoplasm, and presence of constitutional symptoms like fever and weakness should raise the suspicion of RCC


Rob 23: AR PKD most often occurs in

children and could involve the liver; think mutations in PKHD1 gene encoding for fibrocystin expressed in kidney, liver, and pancreas


Rob 25: In this case, drug-induced interstitial nephritis caused by

ampicillin (immunological rxn caused by drug acting as a hapten)


Rob 28: Embryologic urachus may not become obliterated, leaving a

fistulous tract or a cyst b/w the bladder and abdo wall at the umbilicus


Rob 29: Minimal change disease most likely caused by

primary injury to visceral epi cells caused by T cell-derived cytokines that leads to foot process fusion


Rob 31: Medullary sponge kidney shows

cystic dilation of 1-5 mm in the inner medullary and papillary collecting ducts; could see calculi in dilated collecting ducts


Rob 42: Most common cause of nongonococcal urethritis in men is

C trachomatis (think STD!!!)


Rob 44: An anlgesic nephropathy can

damage the renal interstitium and give rise to papillary necrosis; unlikely to get hydronephrosis with no urinary tract obstruction


Rob 52: A patient with nephrocalcinosis due to hypercalcemia could have

metatstatic disease; have chronic tubulointerstitial disease of the kidneys that's initially manifested by loss of concentrating ability and progressive loss of renal function


Rob 57: Patient with malignant HTN can have

necrotizing arteriolitis and hyperplastic arteriolosclerosis