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Cellcykeln > S-fas > Flashcards

S-fas Flashcards

(12 cards)

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1
Q

Start av S-fas: Vad händer med CKI under S-fasen?

A

Degraderas

SCF ubiquitinylerar

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2
Q

Vad händer med S-cyklin/Cdk om det ej skett nån DNA-skada?

A

Desfosforyleras av Cdc25

Cdc25 vinner över Wee1

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3
Q

Vad aktiveras av S-Cyklin/Cdk?

A

Prereplikationskomplex - helikas + kofaktorer

  • kan bara användas 1 gång/cellcykel
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4
Q

Vad är geminin viktigt för?

A

Förhindra återladdning av helikas (ska bara kunna ske i G1)

Fosforylerar till exempel enhet i ORC

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5
Q

Vad heter geminin-inaktivatorn?

A

Cdh1

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6
Q

När bildades prereplikationskomplexet?

A

Under G1

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7
Q

Vad är DDK?

A

Kinas som aktiverar helikas

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8
Q

Vad är ORC?

A

Binder inaktivt helikas och bildar prereplikationskomplexet

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9
Q

När bryts geminin ner?

A

Sen M-fas -> G1

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10
Q

Hur bryts geminin ner?

A

APC/C - ubiquitinylerar

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11
Q

Hur aktiveras APC/C?

A

Binder till cdh1

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12
Q

Hur hämmas cdh1?

A

Av G1-cyklin

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Cellcykeln (8 decks)

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