S1_L2: Neurons, Glia, Receptors, & Nerve Fibers Flashcards

1
Q

Membrane-bound vesicles formed by the budding off of the Golgi apparatus that serves the cell by acting as intracellular scavengers. These contain hydrolytic enzymes and are involved in the process of intracellular digestion.

A

Lysosomes

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2
Q

Which 2 filamentous protein structures provide a stationary track that permits specific organelles to move by molecular motors

A

Microtubules and microfilaments

Source: Snell

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3
Q

Determine the corresponding descriptions of the connective tissue sheaths surrounding a peripheral nerve

  1. connective tissue sheath surrounding bundles of nerve fibers
  2. dense connective tissue sheath surrounding the nerve trunk
  3. loose, connective tissue between individual nerve fibers

A. Endoneurium
B. Perineurium
C. Epineurium

A
  1. B
  2. C
  3. A
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4
Q

Collective term for cranial and spinal nerves and each of these consists of parallel bundles of nerve fibers, which may be efferent or afferent axons, and may be myelinated or unmyelinated

A

Peripheral nerve

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5
Q

TRUE OR FALSE: The central nervous system does not have lymphatic capillaries

A

True

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6
Q

TRUE OR FALSE: Conduction velocity is positively affected by factors such as fiber diameter and myelination

A

True

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7
Q

Determine the corresponding descriptions of the fenestrated & non-fenestrated capillaries of CNS

  1. Located in specialized areas of brain that lack a blood-brain barrier
  2. Ubiquitous in white and gray matter
  3. Endothelial cells with tight junctions are surrounded by a continuous basement membrane & an outer investment of astrocytic foot process
  4. Consists of endothelial cells with fenestrations that permit free passage of blood-borne substances into extracellular spaces of CNS
  5. Endothelial cells & their tight junctions constitute the blood-brain barrier

A. Fenestrated
B. Non-fenestrated

A
  1. A
  2. B
  3. B
  4. A
  5. B
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8
Q

TRUE OR FALSE: The myelin sheath is not part of the neuron but is formed by supporting neuroglial cells

A

True

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9
Q

The plasma membrane of the neurolemma (Schwann’s sheath) that surrounds an axon. It transmits signals from Schwann cells to axons needed for the stability of myelinated axons.

A

Mesaxon

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10
Q

Circular truncated cone shape in the myelin internode and a specific feature of myelinated nerve fibers

A

Schmidt-Lanterman Incisures

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11
Q

A segmented, discontinuous layer interrupted at regular intervals by the Nodes of Ranvier. It serves as the insulator of the nerve fiber and consists of a spirally-wrapped plasma membrane.

A

Myelin sheath

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12
Q

Determine the corresponding descriptions of the myelination in the Peripheral and Central Nervous System

  1. Only 1 fiber is served by the cell
  2. Mesaxon is absent
  3. Cell responsible is the Schwann cell
  4. Cell responsible is the oligodendrocyte
  5. The cell can serve up to 60 nerve fibers

A. Peripheral Nerve
B. CNS Tract

A
  1. A
  2. B
  3. A
  4. B
  5. B
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13
Q

Determine the corresponding functions of the types of sensory axons

  1. Proprioception, Golgi Tendon Organs
  2. Touch, pressure, fast pain, and temperature
  3. Slow pain and temperature, unmyelinated fibers
  4. Proprioception, muscle spindles
  5. Touch, pressure, and vibration

A. Ia (Aα)
B. Ib (Aα)
C. II (Aβ)
D. III (Aδ)
E. IV (C)

A
  1. B
  2. D
  3. E
  4. A
  5. C
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14
Q

Which of these neurons is the largest and the smallest in diameter size?

Choices: Alpha (Aα), Gamma (Aγ), Preganglionic autonomic fibers (B), Postganglionic autonomic fibers (C)

A

Largest: Alpha (Aα)
Smallest: Postganglionic autonomic fibers (C)

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15
Q

Conduction velocity of Ia (Aα) & Ib (Aα) sensory axons

A

70-120 m/s

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16
Q

Conduction velocity of II (Aβ) sensory axons

A

30-70 m/s

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17
Q

Conduction velocity of III (Aδ) sensory axons

A

12-30 m/s

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18
Q

TRUE OR FALSE: Neuroglia are capable of mitotic cell division throughout adult life

A

True

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19
Q

TRUE OR FALSE: Microglia do not form tumors and tumors are derived from astrocytes, oligodendrocytes, and ependymocytes.

A

True

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20
Q

A phenomenon following nerve damage which gives the impression that the Nissl substance has disappeared

A

Chromatolysis

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21
Q

Aka neurilemmal cells. These are derivatives of the neural crest and function in regeneration and remyelination of severed axons in the PNS.

A

Schwann cells

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22
Q

Intercalated or internuncial neurons that interconnect motor or sensory neurons within the central nervous system (CNS)

A

Interneurons

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23
Q

Determine the corresponding functions of the main structures in a nerve cell body

  1. Role in formation and retraction of cell processes and in cell transport
  2. Form the main component of the cytoskeleton; determines the shape of the neuron; consists of spiral protein threads that play a role in developing and regenerating nerve fibers
  3. Cell transport of peptide vesicles and organelles; development and maintenance of cell shape
  4. Controls cell activity
  5. Adds carbohydrate to protein molecule to form glycoproteins; packages products for transport to nerve terminals; active in lysosome production and in the synthesis of cell membranes

A. Nucleus
B. Golgi complex
C. Neurofibrils / Neurofilaments
D. Microfilaments
E. Microtubules

A
  1. D
  2. C
  3. E
  4. A
  5. B
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24
Q

Determine the corresponding functions of the main structures in a nerve cell body

  1. Formation of the spindle during cell division; formation & maintenance of microtubules
  2. Related to formation of dopamine
  3. Form chemical energy, possess many enzymes which take part in the tricarboxylic acid cycle (Krebs or citric acid cycle) and the cytochrome chains of respiration
  4. Synthesizes protein
  5. Harmless metabolic byproduct as the result of lysosomal activity

A. Nissl substance
B. Mitochondria
C. Centrioles
D. Lipofuscin
E. Melanin / Neuromelanin

A
  1. C
  2. E
  3. B
  4. A
  5. D
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25
Q

Determine the corresponding appearance of the main structures in a nerve cell body

  1. Filaments 3-5 nm in diameter, composed of actin
  2. 10 nm in diameter, run parallel to each other through the cell body into the neurites
  3. Pale, chromatin widely scattered; single prominent nucleolus
  4. Run between neurofibrils, 25 nm in diameter
  5. Made up of smooth endoplasmic reticulum

A. Nucleus
B. Golgi complex
C. Neurofibrils / Neurofilaments
D. Microfilaments
E. Microtubules

A
  1. D
  2. C
  3. A
  4. E
  5. B
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26
Q

Determine the corresponding appearance of the main structures in a nerve cell body

  1. Wall made up of bundles of microtubules
  2. Double membrane with the inner membrane thrown into folds or cristae
  3. Yellowish brown-blackish pigment in the neurons of the substantia nigra and locus coeruleus
  4. Broad cisternae; ribosomes are basophilic
  5. Yellowish brown granules within the cytoplasm that accumulate with aging

A. Nissl substance
B. Mitochondria
C. Centrioles
D. Lipofuscin
E. Melanin / Neuromelanin

A
  1. C
  2. B
  3. E
  4. A
  5. D
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27
Q

Determine the corresponding shape of the main structures in a nerve cell body

  1. Irregular wavy threads; clusters of flattened cisternae and small vesicles
  2. Linear tubes
  3. Linear fibrils
  4. Large, rounded

A. Nucleus
B. Golgi complex
C. Neurofibrils / Neurofilaments
D. Microfilaments
E. Microtubules
F. Both C and D

A
  1. B
  2. E
  3. F
  4. A
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28
Q

Determine the corresponding shape of the main structures in a nerve cell body

  1. Lipochrome granules
  2. Small, paired hollow cylinders found in immature dividing nerve cells
  3. Granules of rough endoplasmic reticulum (RER) arranged in the form of broad cisternae stacked one on top of the other
  4. Granules
  5. Spherical, rod shaped

A. Nissl substance
B. Mitochondria
C. Centrioles
D. Lipofuscin
E. Melanin / Neuromelanin

A
  1. D
  2. C
  3. A
  4. E
  5. B
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29
Q

Determine the corresponding location of the main structures in a nerve cell body

  1. Centrally placed, displaced to periphery in cell injury
  2. Run from dendrites through cell body to axon
  3. Concentrated at the periphery of the cytoplasm beneath the plasma membrane where they form a dense network
  4. Close to the nucleus

A. Nucleus
B. Golgi complex
C. Neurofibrils / Neurofilaments
D. Microfilaments
E. Microtubules
F. Both C and E

A
  1. A
  2. F
  3. D
  4. B
30
Q

Determine the corresponding location of the main structures in a nerve cell body

  1. Scattered through cytoplasm
  2. Throughout cytoplasm and proximal part of dendrites, absent from axon hillock and axon
  3. Substantia nigra of midbrain
  4. Confined to cytoplasm of cell body
  5. Scattered throughout the cell body, dendrites, and axons

A. Nissl substance
B. Mitochondria
C. Centrioles
D. Lipofuscin
E. Melanin / Neuromelanin

A
  1. D
  2. A
  3. E
  4. C
  5. B
31
Q

TRUE OR FALSE: Fatigue and injury to the Nissl substance result in its concentration at the periphery of the cell body

A

True

32
Q

Determine the corresponding location of the types of neuroglial cells

  1. Gray matter
  2. Scattered throughout CNS
  3. White matter
  4. In rows along myelinated nerves, surrounding neuron cell bodies

A. Fibrous astrocytes
B. Protoplasmic astrocytes
C. Oligodendrocytes
D. Microglia / Hortega cells

A
  1. B
  2. D
  3. A
  4. C
33
Q

Determine the corresponding function of the types of neuroglial cells

  1. Form myelin in CNS, influence biochemistry of neurons
  2. Provide supporting framework, electrical insulators, limit spread of neurotransmitters, take up K+ ions
  3. Inactive in normal CNS, proliferate in disease and phagocytosis, joined by blood monocytes; Act as immune effector cells during inflammatory diseases
  4. Store glycogen, phagocytic function, take place of dead neurons, conduit for metabolites or raw materials, produce trophic substances

A. Fibrous astrocytes
B. Protoplasmic astrocytes
C. Oligodendrocytes
D. Microglia / Hortega cells

A
  1. C
  2. A
  3. D
  4. B
34
Q

Determine the corresponding structure of the types of neuroglial cells

  1. Wavy branches arise from their small cell bodies that give off numerous spine-like projections
  2. Small cell bodies, few delicate processes, no cytoplasmic filaments
  3. Small cell bodies, long slender smooth processes, cytoplasmic filaments, perivascular feet
  4. Small cell bodies, short thick processes, many branches, few cytoplasmic filaments, perivascular feet

A. Fibrous astrocytes
B. Protoplasmic astrocytes
C. Oligodendrocytes
D. Microglia / Hortega cells

A
  1. D
  2. C
  3. A
  4. B
35
Q

The largest of the neuroglial cells is (1)___, while the smallest is (2)___.

A
  1. Astrocytes
  2. Microglia / Hortega cells
36
Q

Determine the corresponding structure of the types of neuroglial cells

  1. Sides and bases thrown into folds; near their luminal surfaces, the cells are held together by tight junctions that encircle the cells
  2. Cuboidal or columnar in shape with cilia and microvilli, gap junctions
  3. Long basal processes with end feet on blood capillaries

A. Ependymocytes
B. Tanycytes
C. Choroidal epithelial cells

A
  1. C
  2. A
  3. B
37
Q

Determine the corresponding location of the types of neuroglial cells

  1. Lining of floor of third ventricle overlying the median eminence of the hypothalamus
  2. Surface covering of choroid plexuses
  3. Lining of ventricles, central canal

A. Ependymocytes
B. Tanycytes
C. Choroidal epithelial cells

A
  1. B
  2. C
  3. A
38
Q

Determine the corresponding function of the types of neuroglial cells

  1. Produce and secrete CSF
  2. Circulate CSF by movements of the cilia & absorb CSF by presence of microvilli on their free surfaces
  3. Transport substances from CSF to hypophyseal-portal system

A. Ependymocytes
B. Tanycytes
C. Choroidal epithelial cells

A
  1. C
  2. A
  3. B
39
Q

The presence of ___ that encircle and hold together the choroidal epithelial cells prevents the leakage of CSF into the underlying tissues

A

tight junctions

40
Q

Microglia are derived from

A

Monocytes

41
Q

The oligodendrocytes lack glial filaments and ___ granules

A

glycogen

42
Q

Determine the corresponding description of the 3 forms of lysosomes

  1. Lysosomes in which the enzymes are inactive and the bodies evolved from digestible materials such as pigment and lipid
  2. Lysosomes which have just been formed
  3. Lysosomes which contain partially digested material (myelin figures)

A. Primary lysosomes
B. Secondary lysosomes
C. Residual bodies

A
  1. C
  2. A
  3. B
43
Q

These degenerate in Alzheimer’s disease or dementia to form neurofibrillary tangles.

A

Neurofilaments

44
Q

This surrounds the blood capillaries in the brain and spinal cord and provides a pathway for the exchange of ions and molecules between the blood and the neurons and glial cells.

A

Extracellular space

Source: Snell

45
Q

Determine the corresponding descriptions of the types of axonal transport

  1. Mediated by microtubules and dynein
  2. Transports nerve growth factor, neurotropic viruses, and toxins
  3. Transports neurofilaments and microtubules
  4. Mediated by microtubules and kinesin
  5. Occurs at the rate of 50-100mm/day

A. Fast Anterograde Transport
B. Slow Anterograde Transport
C. Fast Mitochondria Transport
D. Fast Retrograde Transport

A
  1. D
  2. D
  3. B
  4. A
  5. C
46
Q

Determine the corresponding descriptions of the types of axonal transport

  1. Returns used materials from axon terminal to cell body for degradation and recycling
  2. Responsible for transporting all newly synthesized membranous organelles (vesicles) and precursors of neurotransmitters at the rate of 200-400mm/day
  3. Responsible for transporting cytoskeletal and cytoplasmic elements at a rate of 1-5 mm/day

A. Fast Anterograde Transport
B. Slow Anterograde Transport
C. Fast Mitochondria Transport
D. Fast Retrograde Transport

A
  1. D
  2. A
  3. B
47
Q

Transection of the optic nerve (CN II) results in degeneration of neurons in the ___

A

lateral geniculate body

48
Q

The collective term for astrocytes and oligodendrocytes

A

Macroglia

49
Q

Determine the corresponding location/example of the morphologic classification of neurons

  1. Cerebral and cerebellar cortex
  2. Sensory neurons in the posterior root
  3. Sensory cochlea
  4. Fiber tracts of brain and spinal cord
  5. Purkinje cells of the cerebellar cortex
  6. Fiber tracts of brain and spinal cord, peripheral nerves, interneurons, and motor cells of spinal cord

A. Unipolar
B. Bipolar
C. Multipolar
D. Golgi type I
E. Golgi type II

A
  1. E
  2. A
  3. B
  4. D
  5. C
  6. C
50
Q

Determine the corresponding location/example of the morphologic classification of neurons

  1. Vestibular ganglia of the vestibulocochlear nerve
  2. Sensory neurons in the cranial nerve ganglia and in the mesencephalic nucleus midbrain
  3. Peripheral nerves and motor cells of spinal cord
  4. Retina and olfactory epithelium
  5. Pyramidal cells of the cerebral cortex
  6. Posterior root ganglion

A. Unipolar
B. Bipolar
C. Multipolar
D. Golgi type I
E. Golgi type II

A
  1. B
  2. A
  3. D
  4. B
  5. C
  6. A
51
Q

TRUE OR FALSE: Golgi type II neurons have a short axon with dendrites resembles a star. These are often inhibitory in function and greatly outnumber type I.

A

True

52
Q

Determine the corresponding descriptions of the tumors of neuroglial cells (gliomas)

  1. Slow-growing, benign circumscribed neoplasms typically found within the ventricles
  2. Most common type of brain cancer & most commonly found in the white matter of the cerebral hemisphere in middle and late life
  3. Slow-growing tumors of mesenchymal origin
  4. Found in the infratentorial compartment and are thought to arise from the external granular layer of the cerebellar cortex
  5. Slow-growing, benign tumors that occur mainly in adults and arise from oligodendroblasts.
  6. Benign tumors of peripheral nerves (usually on vestibulocochlear nerves)

A. Astrocytomas
B. Oligodendrogliomas
C. Ependymomas
D. Schwannomas
E. Meningiomas
F. Medulloblastomas

A
  1. C
  2. A
  3. E
  4. F
  5. B
  6. D
53
Q

One of the two X chromosomes that is compact in the female. It is composed of sex chromatin and sits at the inner surface of the nuclear envelope.

A

Barr body

54
Q

TRUE OR FALSE: The nuclear envelope is continuous with the cytoplasmic rough, or granular, endoplasmic reticulum (RER). It is double layered and possesses fine nuclear pores, through which materials can diffuse into and out of the nucleus.

A

True

55
Q

Determine the corresponding location of the nonencapsulated receptors

  1. Basal layer of epidermis in hairy and glabrous (hairless) skin
  2. Hairy skin
  3. The lower layer of epidermis, the cornea, gut, dermis, ligaments, joint capsules, bone, and dental pulp

A. Free nerve endings
B. Merkel discs / disk
C. Hair follicle receptors

A
  1. B
  2. C
  3. A
56
Q

Determine the corresponding sensory modality of the nonencapsulated receptors

  1. Touch, bending, movement of hair
  2. Pain (fast & slow), touch (crude), pressure, heat and cold, and tickle sensations
  3. Mediate light (crude) touch, 2-point discrimination & project centrally via the spinothalamic tracts and dorsal column-medial lemniscus pathway
  4. Project via spinothalamic tracts

A. Free nerve endings
B. Merkel discs / disk
C. Hair follicle receptors

A
  1. C
  2. A
  3. B
  4. A
57
Q

Determine the corresponding fibers of the nonencapsulated receptors

  1. Free nerve endings
  2. Merkel discs / disk
  3. Hair follicle receptors

A. Aδ (group III fibers), C (group IV fibers)
B. Aβ / group II fibers

A
  1. A
  2. B
  3. B
58
Q

Determine the corresponding adaptability of the nonencapsulated receptors

  1. Free nerve endings
  2. Merkel discs / disk
  3. Hair follicle receptors

A. Rapid
B. Slow

A
  1. A
  2. B
  3. A
59
Q

Determine the corresponding adaptability of the encapsulated receptors

  1. Meissner corpuscles
  2. Pacinian corpuscles
  3. Ruffini corpuscles
  4. Neuromuscular spindles
  5. Neurotendinous spindles

A. Rapid/Fast
B. Slow

A
  1. A
  2. A
  3. B
  4. A
  5. A
60
Q

Determine the corresponding fibers of the encapsulated receptors

  1. Meissner corpuscles
  2. Pacinian corpuscles
  3. Ruffini corpuscles
  4. Neuromuscular spindles
  5. Neurotendinous spindles

A. Aɑ / group Ib fibers
B. Aβ / group II fibers
C. Aɑ, Aβ

A
  1. B
  2. B
  3. B
  4. C
  5. A
61
Q

Determine the corresponding location of the encapsulated receptors

  1. Tendons
  2. Dermal papillae of skin of palm and sole of foot, glabrous (hairless) skin
  3. Skeletal muscle
  4. Dermis, ligaments, joint capsules, peritoneum, external genitalia, mesenteries, and periosteum
  5. Dermis of hairy skin

A. Meissner corpuscles
B. Pacinian corpuscles
C. Ruffini corpuscles
D. Neuromuscular spindles
E. Neurotendinous spindles

A
  1. E
  2. A
  3. D
  4. B
  5. C
62
Q

Determine the corresponding sensory modality of the encapsulated receptors

  1. Vibration & pressure via dorsal column-medial lemniscus pathway; deep touch
  2. Stretch (muscle length)
  3. Fine discriminative touch via dorsal column-medial lemniscus pathway; crude touch; movement of objects
    over the skin
  4. Compression (muscle tension during muscle stretch and contraction)
  5. Stretch / tension, joint position sense, touch and pressure; Hot sensations

A. Meissner corpuscles
B. Pacinian corpuscles
C. Ruffini corpuscles
D. Neuromuscular spindles
E. Neurotendinous spindles

A
  1. B
  2. D
  3. A
  4. E
  5. C
63
Q

A genetic defect in the synthesis of ___ results in a storage disease (Tay-Sachs disease [GM2 gangliosidosis])

A

lysosomal enzyme

64
Q

The synaptic cleft contains ___ that functions for energy storage or structural support

A

polysaccharides

65
Q

Determine the corresponding descriptions of the types of synapse

  1. The rapid spread of activity from one neuron to another ensures that a group of neurons performing an identical function act together
  2. uses neurotransmitters
  3. bidirectional, rare in the human CNS
  4. one neurotransmitter is the principal activator and the others act as modulators
  5. gap junctions containing channels that extend from the cytoplasm of the presynaptic neuron to that of the postsynaptic neuron

A. Chemical synapse
B. Electrical synapse

A
  1. B
  2. A
  3. B
  4. A
  5. B
66
Q

Determine the corresponding descriptions of the types of neuroglial cells

  1. Possess cilia only in embryological stages in man that originate from blepharoplasts (basal bodies), which can be stained by phosphotungstic acid-hematoxylin (PTAH)
  2. “Garbage collectors” of neuroglial cells, macrophages
  3. Contain and give rise to glial filaments and glycogen granules
  4. Consists of interfascicular oligodendrocytes and satellite cells
  5. Play a role in the metabolism of certain neurotransmitters (GABA, serotonin, glutamate)

A. Astrocytes
B. Oligodendrocytes
C. Microglia (Hortega cells)
D. Ependymal cells

A
  1. D
  2. C
  3. A
  4. B
  5. A
67
Q

Arrange the sensory receptors from fastest to slowest.

Choices: merkel’s discs, pacinian corpuscles, pain and temperature receptors, meissner’s corpuscles

A

Fastest to slowest: pacinian corpuscles, meissner’s corpuscles, merkel’s discs, pain and temperature

68
Q

Determine the corresponding descriptions of the following

  1. Receive group Ia primary and group II secondary fibers (flowerspray) and static gamma efferent fibers
  2. Areas responsible for detecting sensation, such as rate of change in length, change in length
  3. Respond primarily to muscle length (static function)
  4. Receive group Ia primary afferent fibers (annulospiral) and static and dynamic gamma efferent fibers
  5. Modify sensitivity of muscle spindles and are co-activated with alpha motor neurons
  6. Respond primarily to rate of change of muscle length (dynamic function)

A. Intrafusal fibers
B. Nuclear bag fibers
C. Nuclear chain fibers
D. Gamma motor neurons

A
  1. C
  2. A
  3. C
  4. B
  5. D
  6. B
69
Q

Determine the corresponding descriptions of the structures associated with neurons

  1. Contain cytoplasm similar in composition to that of the cell body, however no Golgi apparatus is present
  2. Also referred to as soma or perikaryon
  3. Devoid of nissl substance
  4. Sites of functional contact of a nerve cell with another nerve cell, an effector cell, or a sensory receptor cell
  5. Longest process of the cell body
  6. The name given to an axon or a dendrite of a nerve cell

A. Dendrites
B. Axons
C. Synapses
D. Nerve cell body
E. Nerve fibers

A
  1. A
  2. D
  3. B
  4. C
  5. B
  6. E
70
Q

Determine the corresponding descriptions of the structures associated with neurons

  1. During early embryonic development, this is overproduced.
  2. Generate, propagate, and transmit action potential
  3. Fine terminal branches found at the peripheral end of the axon at the receptor site
  4. End distally in terminal boutons in synapses with neurons, muscle cells, and glands
  5. Originate from a small conical elevation on the cell body
  6. Remain plastic throughout life and elongate and branch or contract in response to afferent activity.

A. Dendrites
B. Axons
C. Synapses
D. Nerve cell body
E. Nerve fibers

A
  1. A
  2. B
  3. A
  4. B
  5. B
  6. A
71
Q

TRUE OR FALSE: Normal neurons in the mature individual do not undergo division and replication.
Neurons can recover and improve even when injured, however, there are no schwann cell basement membranes or endoneurial investments surrounding the axons of the CNS. Thus, effective regeneration does not occur in the CNS.

A

True

72
Q

Determine the corresponding descriptions of the inclusion bodies

  1. Intracytoplasmic inclusion bodies found in people with rabies
  2. Eosinophilic – will stain (pinkish in color)
  3. Eosinophilic intracytoplasmic inclusion bodies found in substantia nigra in patients with Parkinson’s disease
  4. Disappears from the substantia nigra and the locus coeruleus in Parkinson’s disease
  5. Intracytoplasmic inclusion bodies found in the hippocampus in patients with Alzheimer’s disease

A. Lewy bodies
B. Hirano bodies
C. Negri and Less bodies
D. Neuromelanin
E. Lipofuscin

A
  1. C
  2. E
  3. A
  4. D
  5. B