Salivary Gland Disorders Flashcards

(73 cards)

1
Q

8 salivary gland disorders

A
  1. Mucocele/Ranula
  2. Sialolithiasis
  3. Acute/Chronic Sialadenitis
  4. Sialadenosis
  5. Xerostomia
  6. Benign Lymphoepithelial Lesion (BLEL)
  7. Sjogren Syndrome
  8. Necrotizing Sialometaplasia
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2
Q

Disorder: Common cause of oral mucosal swelling

A

Mucocele

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3
Q

Mucoceles are caused by rupture of the salivary gland ___ and spillage of ____

A

Duct, mucin

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4
Q

Most common region for mucocele

A

Lower lip

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5
Q

A type of mucocele seen on the FOM

A

Ranula

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6
Q

A ranula arises from the ___ gland

A

Sublingual

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7
Q

Where are ranulas seen?

A

FOM, right or left of midline

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8
Q

Histologically: you see ___ and ____ tissue in a mucocele and ranula

A

Mucin and granulation tissue

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9
Q

What must you rule out in a mucocele?

A

Neoplasm

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10
Q

What must you excise with a mucocele?

A

The involved gland

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11
Q

Treating a ranula may include ____

A

Marsupialization

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12
Q

Disorder: Calcified structures which develop within the salivary ducts

A

Sialolithiasis

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13
Q

Sialolithiasis have deposition of ___ salts around nidus of ____ in lumen

A

Calcium, debris

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14
Q

2 potential causes of sialolithiasis

A

Chronic sialadenitis (viral/bacterial), Partial duct obstruction

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15
Q

Are sialolithiasis hard or soft?

A

Hard

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16
Q

___% of sialolithiasis come from the ____ gland

A

80%, submandibular

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17
Q

Radiographic sialolithiasis feature

A

Opaque, lamellated structure

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18
Q

Histologically: sialolithiasis shows concentric ____ surrounding ____

A

Laminations, debris

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19
Q

Sialolithiasis may demonstrate ____ ____ if the duct is removed

A

Squamous metaplasia

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20
Q

Treatment for sialolithiasis

A

Increase saliva, moist heat, massage, removal of gland

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21
Q

Prognosis for sialolithiasis

A

Good for minor glands. Morbidity if major gland requires removal

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22
Q

Disorder: Inflammation of the salivary gland

A

Acute/Chronic Sialadenitis

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23
Q

Causes of Sialadenitis

A

Bacterial, Viral, Ductal obstruction/retrograde infection

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24
Q

Cause of bacterial Sialadenitis

A

Penicillinase-producing staph

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25
Cause of viral Sialadenitis
Mumps
26
Cause of ductal obstruction/retrograde infection leading to Sialadenitis
Xerostomia, may follow general anesthesia
27
Chronic Sialadenitis may follow acute Sialadenitis due to ___ damage
Ductal
28
Difference in Sialadenitis in Sialolithiasis
Sialadenitis is diffuse and sialolithiasis is localized
29
Is Sialadenitis painful?
Yes (note: it's INFLAMMATION)
30
Gland mostly involved in acute Sialadenitis
Parotid
31
Gland mostly involved in chronic Sialadenitis
Submandibular
32
What used to be used radiographically for Sialadenitis
Sialography
33
4 things seen in Sialadenitis, histologically
Inflammatory cells, dilated ducts, acinar atrophy, fibrosis
34
Prognosis for acute Sialadenitis
Higher mortality due to spread of infection
35
Disorder: associated with underlying systemic conditions
Sialadenosis
36
Sialadenosis treatment
Control of underlying condition, pilocarpine (saliva stimulator) use
37
Sialadenosis prognosis
Fair, depending on underlying disease
38
#1 cause of xerostomia
Medications, especially polypharmacy
39
Disorder: Autoimmune condition with a proliferation of epithelial cells and lymphocytes
Benign Lymphoepithelial Lesion
40
BLEL is mainly ___ and ___ glands
Parotid and lacrimal
41
BLEL alone may represent an isolated form of ___ ___
Sjogren syndrome
42
BLEL has a ____ predilection
Female
43
What does sialography show for BLEL
"Blossoms on a tree": Puctate sialectasis
44
For the histology of BLEL, what replaces normal parotid parenchyma
Diffuse lymphocytic infiltrate
45
What might you see occasionally in the histology of BLEL
Germinal centers
46
What must be IDed in BLEL histology? Where else can they be seen?
Epimyoepithelial islands, lymphoma
47
Prognosis for BLEL
Good - but malignant transformation has been reported
48
2 forms of Sjogren's Syndrome
Primary (sicca syndrome - xerostomia and dry eyes) | Secondary (sicca syndrome & any other autoimmune disease)
49
Sjogrens has a huge ___ predilection
Female (9:1)
50
____ swelling (BLEL) may be seen in Sjogren syndrome
Parotid
51
What do Sjogren patients complain of?
Dry, gritty eyes and dry mouth
52
Serology for Sjogren syndrome is relatively ______
Non-specific
53
Patients with Sjogren syndrome tend to have elevated _____ _____ _____ and _____, especially ____
Erythrocute Sedimentation Rate (ESR), polyhypergammaglobulinema, IgG
54
Sjogren syndrome patients have positive ____ and ____ antibodies
RF, Anti-nuclear
55
2 ANAs (Anti-nuclear Antibodies) in Sjogren syndrome
Anti-SS-A (anti-Rho) and Anti-SS-B (anti-La)
56
Biopsy to diagnose Sjogren syndrome
Labial salivary gland biopsy
57
How many minor glands must you remove in a labial salivary gland biopsy for Sjogren syndrome?
5 minor glands
58
Which parts of the gland are excluded from a Sjogren diagnosis and why?
Lobules exhibiting acinar atrophy and interstitial fibrosis. They are non-specific features related to aging
59
Histologically, what supports the diagnosis of Sjogren
1 or more foci of 50 or more cells per 4 mm^2 of glandular tissue
60
Treatment of Sjogren
Artificial tears and increased saliva
61
Patients with Sjogren syndrome are more at risk for ___
Lymphoma
62
Disorder: thought to be due to ischemic necrosis
Necrotizing Sialometaplasia
63
Necrotizing Sialometaplasia has a ____ predilection
Male
64
Most common location for Necrotizing Sialometaplasia
Posterior hard palate/anterior soft palate
65
After 2 weeks, patients with Necrotizing Sialometaplasia will say:
"A piece of my palate fell out"
66
Necrotizing Sialometaplasia heals in __-___ weeks
4-6
67
Necrotizing Sialometaplasia can be mistaken for ___ or ____ carcinoma
SCC, mucoepidermoid
68
What do you see in the surface epithelium of Necrotizing Sialometaplasia
Pseudoepitheliomatous hyperplasia (PEH)
69
Histologically, what mimics SCC in Necrotizing Sialometaplasia
Nonspecific reactive hyperplasia stratified mucocutaneous epithelia
70
Constant hypersalivation
Sialorrhea
71
2 causes of sialorrhea
Increased salivary flow (primary) and impaired swallowing (secondary)
72
Most common reason for impaired swallowing
neuromuscular dysfunction
73
Treatments for sialorrhea
Surgery and Botox