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Flashcards in Sample's Material Deck (105)
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1

What is the major regulatory enzyme for Thrombopoiesis?

Thrombopoietin

2

Where does Thombopoietin come from?

Continually produced by the liver, bone marrow, endothelium ect.

3

______ stimulates megakaryocyte production and differentiation

Thrombopoietin

4

Thrombopoietin binds to _____ in ciruclation

Platelets

5

When _____ numbers decrease there isn't enough in ciruclation to pick up the thrombopoeitin, leading to increased thrombopoietin free in plasma that ciruclates to the bone marrow and stimulates production of _____

Platelets

Megakaryocytes

6

Platelets are part of _____ hemostasis

Primary

7

_____ Provides a surface for which secondary hemostasis occurs on

Platelets

8

How long does it take to form the primary hemostatic plug?

3-5 minutes

9

In the formation of the primary hemostatic plug, platelets adhere to exposed ______

Subendothelium

10

Once platelets adhere to subendothelium they undergo ____, leading to a shape change

Activation

11

After platelets are activated, they begin to secrete _____

Granules

12

After platelets have activated and secreted granules, they _____ to form a platelet plug

Aggregate

13

For platelets to adhere to the subendothelium they require ______Factor

Von Willebrand factor

14

Von Willebrand factor binds to ____ on the platelet surface and forms a bridge between the platelets and subendothelium

GP1b

15

During primary hemostasis, when platelets ____ , they start to undergo shape changes where they grow long extensions and increase their surface area by 3-5%

Activation

*Increase their surface area

16

The majority of negatively charged phospholipids are kept on the inside of the platelet, but when the platelet becomes activated they _____ their membrane in order to carry the negative charge on the outside

Flip

17

After platelets become activated, what two things are secreted in their granules?

Von Willibrand factor

Calcium

*Von willebrand factor calls more platelets to the site 

18

During activation platelets secrete _____ which comes and coats the top of the negatively charged platelets, so the platelets become positively charged

Calcium

19

Calcium is secreted in platelet granules that coat the platelet with a positive charge which is important for creating the surface for the _____ factors to come down and bind to form fibrin

Coagulation

20

Once the granules are stimulated to form platelet aggregation, _____ binds to the platelets and starts bridging the adjacent platelets.

Fibrinogen

21

When _____ binds to activated platelets and bridges adjacent platelets is when you get formation of the platelet plug

Fibrinogen

22

True/False: Platelet aggregation is a reversible process

False

*Irreversible

23

Platelets provide a surface for formation and deposition of ____

Fibrin

24

Platelets activate their cytoskeleton to _____ the clot in order to facilitate wound closure and vessel patency

Retract

25

What laboratory tests are used to assess platelet concentration?

Blood Smear

Hematology analyzers

26

Spontaneous hemorrhage occurs when platelet numbers decrease below ______

20,000

27

What laboratory tests do we use to access platelet morphology?

Blood Smear

Hematology Analyzers

28

Increased MPV suggests increased ______

Thrombopoiesis

 

29

What does the presence of macrothromobocytes suggest?

Increased platelet production

30

What are the tests used in the clinical setting to evaluate platelet function?

Bleeding tests

*Buccal mucosal bleeding time or cuticle (toenail) bleeding time