[sarcoidosis] Flashcards
(60 cards)
1
Q
A
HLA-DRB1
HLA-DQB1
2
Q
A
erythema nodosum
polyarthralgia
3
Q
A
erythema nodosum
polyarthralgia
4
Q
A
inflammatory cells
5
Q
A
inflammatory cells
6
Q
A
inflammatory cells
7
Q
A
CXR
8
Q
A
BHL
bilateral hilar lymphadenopathy
9
Q
A
BHL
bilateral hilar lymphadenopathy
10
Q
A
bilateral hilar lymphadenopathy
lung fibrosis
pulmonary infiltrates
11
Q
A
Dry
12
Q
A
progressive
13
Q
A
progressive cough
dyspnoea
chest pain
14
Q
A
uveitis
Keratoconjuctivitis sicca
glaucoma
conjuctivitis
15
Q
A
parotid
lacrimal
16
Q
A
cardiomyopathy
arrhythmias
17
Q
A
hepatomegaly
splenomegaly
18
Q
A
SOL
meningitis
Bells palsy
19
Q
A
hypercalciuria
20
Q
A
inflammatory cells (non-caseating granulomas)
21
Q
A
hypercalciuria
22
Q
A
Ca2+ increased
23
Q
A
increased
24
Q
A
ACE
non-specific
25
[sarcoidosis]: Ix: serum levels of ... enzyme are raised in 60% and fall with resolution
ACE
| non-specific
26
[sarcoidosis]: Ix: The Mantoux skin test is classically positive or negative
negative
| + think TB as well
27
[sarcoidosis]: Ix: The Mantoux skin test is classically positive or negative
negative
| + think TB as well
28
[sarcoidosis]: Ix: what is the golden Ix?
CXR
29
[sarcoidosis]: how many classification stages can be made on CXR?
4
30
[sarcoidosis]: what is stage 0
normal CXR
31
[sarcoidosis]: define stage 1? (1)
BHL (lymphadenopathy)
32
[sarcoidosis]: define stage 2 (2)
BHL
+
peripheral pulmonary infiltrates (parenchymal lung disease)
33
[sarcoidosis]: define stage 3 (1)
peripheral pulmonary infiltrates alone
34
[sarcoidosis]: define stage 4 (1)
pulmonary fibrosis
35
[sarcoidosis]: define stage 4 (1)
pulmonary fibrosis / honeycombing
36
[sarcoidosis]: what is pulmonary honeycombing
diffuse pulmonary fibrosis (multiple bulla formation)
37
[sarcoidosis]: what is ground glass opacification
diffuse increased opacification with preservation of vascular and bronchial markings
38
[sarcoidosis]: what is ground glass opacification
diffuse increased opacification with preservation of vascular and bronchial markings
39
[sarcoidosis]: would this display obstructive or restrictive lung function?
restrictive
40
[sarcoidosis]: Ix: what is the golden diagnostic Ix?
tissue biopsy
41
[sarcoidosis]: would this display obstructive or restrictive lung function?
restrictive
42
[sarcoidosis]: Ix: what would be seen on tissue biopsy
non-caseating granulomas
43
[sarcoidosis]: what is the difference between caseating and non-caseating granulomas
caseating = necrosis present (dead cells)
44
[sarcoidosis]: Ix: what would increased neutrophils on BAL indicate
pulmonary fibrosis
45
[sarcoidosis]: Ix: what would increased lymphocytes on BAL indicate
active disease
46
[sarcoidosis]: Ix: what would increased lymphocytes on BAL indicate
active disease
47
[sarcoidosis]: Ix: what would be seen on XRAY of the hands
terminal phalanges = punched out lesions
48
[sarcoidosis]: why are renal stones formed
hypercalciuria
49
[sarcoidosis]: Ix: what would be found in the urine and blood
Ca2+ increased
50
[sarcoidosis]: Ix: what would be seen on XRAY of the hands
terminal phalanges = punched out lesions
51
[sarcoidosis]: Tx: what is the Tx up to stage 1?
spontaneous resolvement
| NSAIDs
52
[sarcoidosis]: Tx: what are the indications for drug therapy? (5)
```
Cardiac involvement
Neurological involvement
pulmonary infiltrates
uveitis
hypercalcaemia
```
53
[sarcoidosis]: Tx: what is the treatment for >stage 1 sarcoid
prednisolone 40mg/24hrs PO for 4-6 weeks
54
[sarcoidosis]: Tx: what is the treatment for >stage 1 sarcoid
prednisolone 40mg/24hrs PO for 4-6 weeks
55
[sarcoidosis]: Tx: what is the Tx if severe?
Methylprednisolone IV
56
[sarcoidosis]: Tx: what is the Tx if severe?
Methylprednisolone IV
57
[sarcoidosis]: ∆∆s for BHL: how many ∆∆ are there for BHL
6
58
[sarcoidosis]: ∆∆s for BHL: what are the 6 ∆∆s (6)
```
infection
malignancy
sarcoidosis
organic dust disease
EAA
Histocytosis X
```
59
[sarcoidosis]: ∆∆s for BHL: give 2 examples of infections that can cause BHL
TB
| mycoplasma
60
[sarcoidosis]: ∆∆s for BHL: in particular what cancer can cause BHL
lymphoma
