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PHA 051 - MEDICINAL ORG. CHEMISTRY > SAS 10 > Flashcards

SAS 10 Flashcards

1
Q

Have a nucleus 4 fused cyclic rings

Tetracyclines
Aminoglycosides
Macrolide
Lincomycins

A

Tetracyclines

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2
Q

Most popular antibiotic of tetracycline

Rolitetracycline
Demeclocycline
Oxytetracycline
Tetracycline

A

Tetracycline

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3
Q

Treats acne vaginalis

Tetracycline
Oxytetracycline
Demeclocycline
Rolitetracycline

A

Tetracycline

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4
Q

Made by condensing tetracycline w pyrrolidine & formaldehyde in the presence of tert-butyl alcohol.

Rolitetracycline
Demeclocycline
Oxytetracycline
Tetracycline

A

Rolitetracycline

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5
Q

From Streptomyces aureofaciens

Chlortetracycline HCL
Demeclocycline
Oxytetracycline
Methacycline

A

Chlortetracycline HCL

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6
Q

From mutated Streptomyces aureufaciens

Chlortetracycline HCL
Demeclocycline
Oxytetracycline
Methacycline

A

Demeclocycline

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7
Q

Most potent tetracycline

Minocycline HCL
Glycylcyclines
Doxycycline
Methacycline HCL

A

Minocycline HCL

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8
Q

IS IT TRUE OR FALSE: Aminoglycosides contains 3 rings that has either amino acid and sugar molecules

A

TRUE

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9
Q

which sugar molecules can contain amino substituent

A

Hexose

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10
Q

what are anti-bacterial that binds to 30s subunits?

A

Aminoglycosides
Tetracyclines

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11
Q

From streptomyces griseus

Streptomyces HCL
Streptomyces sulfate

A

Streptomyces sulfate

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12
Q

Agent of choice for treatment of certain occupational bacterial infections

Neomycin sulfate
Kanamycin sulfate
Gentamicin sulfate
Streptomyces sulfate

A

Streptomyces sulfate

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13
Q

From Streptomyces kanamycincetus

Neomycin sulfate
Kanamycin sulfate
Gentamicin sulfate
Streptomyces sulfate

A

Kanamycin sulfate

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14
Q

Semisynthetic derivative of Kanamycin A

A

Amikacin

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15
Q

From micromonospora purpurea

Neomycin sulfate
Kanamycin sulfate
Gentamicin sulfate
Streptomyces sulfate

A

Gentamicin sulfate

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16
Q

micin is from

A

Micromonospora

17
Q

From Streptomyces tenebrarius

Neomycin sulfate
Kanamycin sulfate
Tobramycin sulfate
Streptomyces sulfate

A

Tobramycin sulfate

18
Q

From spectinomycin spectabilis

Neomycin sulfate
Kanamycin sulfate
Tobramycin sulfate
Streptomyces sulfate
Streptomyces HCL

A

Streptomyces HCL

19
Q

Streptomyces fradiae
Streptomyces sepctabilis

partner up:
Streptomyces HCL
Streptomyces sulfate

A

Streptomyces fradiae - Streptomyces sulfate
Streptomyces spectabilis - Streptomyces HCL

20
Q

What are the tetracyclines that shows the least in vitro calcium binding?

A

MOD
(M) inocycline
(O) xytetracycline
(D) oxycycline

21
Q

From Streptomyces Erythraeus

Erythromycin
Clarithromycin
Azithromycin
Troleandomycin

A

Erythromycin

22
Q

Prototype of azalides, the nitrogen-containing 15-membered ring of macrolides.

Erythromycin
Clarithromycin
Azithromycin
Troleandomycin

A

Azithromycin

23
Q

The most potent inhibitor of CYP 450 enzymes of the commercially available macrolides.

Erythromycin
Clarithromycin
Azithromycin
Troleandomycin

A

Troleandomycin

24
Q

One of the most potent agents available against some non-spore-forming anaerobic bacteria

Lincomycin HCL
Clindamycin HCL
Clindamycin phosphate

A

Clindamycin HCL

25
Q

Inhibits cell synthesis

Teicoplanin
Bacitracin
Vancomycin
Gramicidin

A

Vancomycin

26
Q

impairs cell wall synthesis

Teicoplanin
Bacitracin
Vancomycin
Gramicidin

A

Teicoplanin

27
Q

Acts as ionophore in bacterial cell

Teicoplanin
Bacitracin
Vancomycin
Gramicidin

A

Gramicidin

28
Q

Prodrug of chloramphenicol intended for pediatric use

Chloramphenicol palmitate
Chloramphenicol sodium succinate

A

Chloramphenilcol palmitate

29
Q

From pseudomonas fluorescens

A

Mupirocin

30
Q

Classified as ketolide

A

Telithromycin

31
Q

From Streptomyces Fradiae

A

Neomycin sulfate

32
Q

Used in abdominal surgery to control bacterial flora

A

Neomycin sulfate

PHA 051 - MEDICINAL ORG. CHEMISTRY (13 decks)

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