SAS 6

Question 1

what are the 3 polyenes antibiotic?

Answer 1

Amphotericin B, Natamycin, Nystatin

Question 2

extracted from streptomyces noursei

Answer 2

Nystatin

Question 3

extracted from streptomyces natalensis

Answer 3

Natamycin

Question 4

extracted from streptomyces nodosus

Answer 4

Amphotericin B

Question 5

what is the active constituent of flucytosine?

Answer 5

5-fluorouracil

Question 6

what is fluorouracil can act on?

Answer 6

RNA AND DNA

Question 7

this is administered with amphotericin B to prevent resistance?

Answer 7

Flucytosine

Question 8

what are the 3 phenols under antifungal?

Answer 8

Ciclopirox Olamine - CLPO
Clioquinol - Clioqui
Haloprogin

Question 9

PHENOL: agent of choice in the treatment of cutaneous candidiasis, tinea corporis….

Answer 9

Ciclopirox olamine

Question 10

PHENOL: the second line of choice for the treatment of onychomycosis

Answer 10

Ciclopirox olamine

Question 11

other words of clioquinol?

Answer 11

Vioform

Question 12

Vioform is best for?

Answer 12

Jock itch and athlete’s foot

Question 13

cure rates is high but expensive

Answer 13

Haloprogin

Question 14

From caprylic acid

Answer 14

Sodium caprylate

Question 15

this requires the use keratolytic agent

Answer 15

Benzoic acid

Question 16

what is the old but famous formulation of benzoic acid?

Answer 16

Whitfield’s ointment
6% benzoic acid
6% salicylic acid

Question 17

is one of the better fatty acids for use as a fungicide although low cure rates

Answer 17

Undecylenic acid

Question 18

is used as a fungicide particularly on adhesive tape

Answer 18

Zinc propionate

Question 19

a mitotic spindle poison

Answer 19

Griseofulvin

Question 20

INHIBITS SQUALENE EPOXIDASE that is for ergosterol synthesis

Answer 20

Allylamines

Question 21

ALLYLAMINES: 1% conc. of cream and gel for topical-related fungal infections

Answer 21

Naftifine

Question 22

ALLYLAMINES: has not been approved in the US for oral administration

Answer 22

Terbinafine

Question 23

ALLYLAMINES: 1% in creams, powders, aerosols, gels, and solutions for topical-related fungal infection.

Answer 23

Tolnaftate

Question 24

inhibits Ianosterol 14-demethylase

Answer 24

Azole antifungals agent

Question 25

More effective against Torulopsis glabrata than other azoles

Answer 25

Tioconazole

Question 26

has an adverse effects of hepatoxicity and problems with sex hormones

Answer 26

Ketoconazole

Question 27

an important substitution of ketoconazole

Answer 27

Itraconazole

Question 28

why itraconazole is better substituent than the ketoconazole?

Answer 28

more effective and none ketoconazole's adverse effects

Question 29

contains two triazole moieties and has an exception of being soluble in water

Answer 29

Fluconazole

Question 30

Approved for the treatment of invasive aspergillosis and refractory infections Scedosporium apiospermum and Fusarium spp

Answer 30

Fluconazole

Question 31

a class of antifungal that targets fungal cell wall

Answer 31

Echinocandins

Question 32

an antifungal agent that is non-toxic and non-irritant

Answer 32

Propionic acid

Question 33

prepared from caprylic acid

Answer 33

Sodium caprylate

Question 34

adhesive type antifungal agent

Answer 34

Zinc propionate

Question 35

obtained from distillation of castor oil

Answer 35

10-undenoic acid

Question 36

its efficacy is from the release of acetic acid

Answer 36

Triacetin

Question 37

poor antifungal agent

Answer 37

keratolytics

Question 38

beside athletes foot and jock's itch what does clioquinol can treat?

Answer 38

Trichomonas vaginalis vaginitis

Question 39

what is the drug in flucytosine in RNA?

Answer 39

Fluororibonucleotide triphosphate

Question 40

what is the drug in flucytosine in DNA?

Answer 40

5-Fluorodeoxyuridine monophosphate

Question 41

a 26 membered ring in polyenes

Answer 41

Natamycin (streptomyces natalensis)

Question 42

what does inhibition of squalene oxidase does to do a fungi cell?

Answer 42

interruption in the biosynthesis of ergosterol

Question 43

what are the imidazoles

Answer 43

BECTOMKS Butoconazole Econazole Clotrimazole TIOCONAZOLE Oxiconazole Miconazole Ketoconazole Sulconazole

Question 44

what are the triazoles

Answer 44

VFPIT Voriconazole Fluconazole Posaconazole Itraconazole TERCONAZOLE

Question 45

for patients 13 years and above

Answer 45

Posaconazole

Question 46

treatment of burns

Answer 46

Nitrofurazone

Question 47

treatment of UTI caused by susceptible strains of E. coli

Answer 47

Nitrofurantoin

Question 48

inhibits squalene epoxidase

Answer 48

Allylamines (naftifine, tolnaftate, terbinafine)