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PHA 069_MANUFACTURING > SAS 6 COMPLETE > Flashcards

SAS 6 COMPLETE Flashcards

1
Q

What are the widely used substance in semisolids next to water?

A

Petrolatum and mineral oil

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2
Q

is a complex mixture of semisolids containing hydrocarbon aliphatic, cycle, saturated, unsaturated branch and unbranched substances in varying proportions.

A

Petrolatum

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3
Q

this is employed to increase the viscosity of mineral oil to prevent separation from the ointment

A

Hydrocarbon wax
example: paraffin and ceresin wax

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4
Q

are used in water removable creams as an emulsifier to develop a certain consistency in the cream.

A

stearic acid

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5
Q

are used in creams as auxiliary emulsifiers and emollients.

A

stearyl alcohol and cetyl alcohol

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6
Q

what are the 4 classes of semi-solid vehicles

A

Hydrocarbon vehicle
Absorption vehicle
water removable vehicle
water soluble vehicle

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7
Q

also known as greaseless ointment bases

A

water-soluble vehicle

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8
Q

____________ is the most commonly used in ointment vehicles.

A

Petrolatum

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9
Q

examples of absorption base

A

lanolin, cholesterol, sterols, sorbitan monostearate, monoolate

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10
Q

between water removable and absorption base which is w/o and o/w

A

w/o is absorption base whereas, o/w is water removable

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11
Q

anhydrous ointments are manufactured by this method.

A

Fusion method

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12
Q

this rectal suppository is intended to relief nausea, vomiting, and as tranquilizer

A

Prochlorperazine and Chlorpromazine

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13
Q

this rectal suppository is intended as opioid analgesia

A

morphine and oxymorphone

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14
Q

this rectal suppository is intended for anti-inflammatory analgesic and analgesic and antipyretic

A

Indomethacin

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15
Q

this rectal suppository relieves nausea and vomiting

A

Ondansetron

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16
Q

the majority of the components melt at rectal temperature of _______.

A

36 celsius

17
Q

Most frequently employed suppository base

A

Oleaginous base

17
Q

Most common base used for rectal suppository

A

Cocoa butter

18
Q

Made from triglycerides from palm, palm kernel, and coconut oils with self-emulsifying glyceryl monostearate and polyoxyl stearate.

A

Fattibase

19
Q

From triglycerides derived from coconut oil

A

Wecobee

20
Q

From triglycerides of saturated fatty acid C12-C18

A

Witepsol

21
Q

Most frequently used in preparation of vaginal suppository

A

Glycerinated gelatin

22
Q

this base does not melt on body temperature but rather dissolve slowly in the body’s fluid.

A

Polyethyleme glycols

23
Q

also called macromelting range test

A

melting range test

24
Q

measures the liquefaction time of rectal suppositories in an apparatus that IN-VIVO condition

A

Liquefaction/softening time test

25
Q

the rate IN-VITRO release of drug substance from suppositories

A

Dissolution testing

26
Q

designed as a method for measuring the fragility or brittleness of suppository.

A

Breaking test

27
Q

are sterile, small, usually cylindrical-shaped solid objects 3.3mm in diameter and 8mm in length.

A

Pellets

28
Q

what is the most used vehicles for sterile product

A

water

29
Q

polyethylene glycol, propylene glycol, fixed oil, and benzyl benzoate are examples of…

A

Sterile: Non-aqueous solution:

30
Q

what type of glass is preferred for parenterals

A

Type I: Highly resistant borosilicate glass

31
Q

what type of glass is preferred for buffered aqueous solution and for dry powders and oleaginous solution

A

Type II: Treated soda lime glass

32
Q

what type of glass is preferred for dry powders and oleaginous solutions.

A

Type III: Soda lime glass

33
Q

what type of glass is preferred for tablets, oral solutions, suspensions, ointments, and extractives.

A

Type NF: General purpose soda lime glass

PHA 069_MANUFACTURING (18 decks)

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