SAS 7

Question 1

A reaction between two or more drugs or between a drug and a food beverage or supplement

Answer 1

Drug interaction

Question 2

It is the modification of the therapeutic effect of one drug by the prior concominant administration of another

Answer 2

Therapeutic incompatibility

Question 3

Any noxious or unintended reaction to a drug that is administered in standard doses by the proper route for the purpose of prophylaxis, diagnosis or treatment

Answer 3

ADR Adverse Drug Reactions

Question 4

An action of a drug on the effectiveness or toxicity of another drug

Answer 4

Drug interaction - a.k.a drug-adjuvant interaction

Question 5

Precipitant drug

Answer 5

Responsible

Question 6

Object drug

Answer 6

Affected

Question 7

Occurs when one drug enhances or interferes with the absorption, distribution, metabolism or excretion of another drug resulting in a change in drug concentration in the body or the duration of the drug’s availability at the receptor sites

Answer 7

Pharmacokinetic interactions (ADME)

Question 8

When a precipitant drug affects the absorption of an object drug, the concentration of the drug in the plasma is either increased or decreased

Answer 8

Alteration in absorption

Question 9

Absorption of some drugs from GIT is dependent on the pH of the fluid in absorption site

Answer 9

Alreration in the Gastric pH

Question 10

Ketoconazole+Antacid

Answer 10

Alteration in Gastric pH

Question 11

Bisacodyl+Antacid

Answer 11

Alteration in Gastric pH

Question 12

Some drugs may form irreversible chelates in the presence of another drug rendering both drugs inactive

Answer 12

Complexation

Question 13

Tetracycline + Metals

Answer 13

Complexation

Question 14

Fluoroquinolones + Metals

Answer 14

Complexation

Question 15

Penicillamine + Metal-containing drugs

Answer 15

Complexation

Question 16

Non-specific binding of a drug to another agent

Answer 16

Adsorption

Question 17

Cholestyramime + warfarin = thrombosis

Answer 17

Adsorption

Question 18

the time it takes for the stomach to empty it’s content

Answer 18

Gastric Empting Time

Question 19

Cathartics + Antacid

Answer 19

Alteration in GET

Question 20

Atropine + Antacid

Answer 20

Alteration in GET

Question 21

OCP + Antibiotic = unwanted pregnancy

Answer 21

Alteration in GI Flora

Question 22

displacement from plasma protein binding site

Answer 22

Alteration in Distribution

Question 23

Phenylbutazone + Warfarin = hemorrhage

Answer 23

Alreration in Distribution

Question 24

Sulfonamides + OHA = hypoglycemia

Answer 24

Alteration in Distribution

Question 25

Process by which drugs are converted into more.polar and hydrophilic molecules to make it easier to eliminate through the kidneys

Answer 25

Metabolism

Question 26

Process by which a drug or molecule enhances the action kf an enzyme towards another drug resulting in a faster inactivation of drug

Answer 26

Enzyme induction

Question 27

Phenobarbital + Warfarin = thrombosis

Answer 27

Enzyme induction

Question 28

process by which a drug or molecule inhibits the action of an enzyme towards another drug resulting in a slower rate of metabolism

Answer 28

Enzyme inhibition

Question 29

NaHCO3 + ASA

Answer 29

Alteration in urinary pH

Question 30

Penicillin + Probenecid

Answer 30

Alteration in Active transport

Question 31

Occur when one drug alters the effect of another drug at its site of action without altering the systematic concentration of a drug

Answer 31

Pharmacodynamic interaction

Question 32

Concurrent administration of two drugs acting on the same mechanism, the final effect of which is the same as the algebraic sum of their separate effects

Answer 32

Addition

Question 33

BZD + Antihistamine = sedation

Answer 33

Addition

Question 34

Beta blockers + Non-DHPs

Answer 34

Addition

Question 35

Results when two drugs on similar mechanism enhance the action of each other to produce an effect much greater than the sum of each drug acting separately

Answer 35

Synergism

Question 36

Occurs when two drugs acting on different mechanism or receptors are raken together and one of them intensifies the action of the other

Answer 36

Potentiation

Question 37

Amoxicillin + Clavulanic acid

Answer 37

Potentiation

Question 38

Ampicillin + Sulbactam

Answer 38

Potentiation

Question 39

Piperacillin + Tazobactam

Answer 39

Potentiation

Question 40

Legodopa + Carbidopa

Answer 40

Potentiation

Question 41

Two drugs with opposing action may result in the reduction or cancellation of the effect of one or drug drugs

Answer 41

Antagonism

Question 42

Naloxone + Morphine

Answer 42

Antagonism

Question 43

Warfarin + Green Leafy Vegetables

Answer 43

Drug-Food interaction

Question 44

Spironolactone + Banana

Answer 44

Drug-food interaction

Question 45

Rifampicin + Urinalysis

Answer 45

Drug-Laboratory Interactions