Schizophrenia Flashcards
(15 cards)
What are the positive symptoms
Hallucination
Delusions
Negative symptoms
Social withdrawal
Blank facial expressions
1st line managemnt
CBT + antipsychotics if first epidose
Moa of first generation antipsychotics
Block dopamine
2nd gen moa
Blocks dopamine and seritonin
Examples of 1st generation
Haloperidole
Chlorpromizine
Examples of second gen
Aripirazole
Olnazapine
Risperidone
Quitipine
Clozapine
Which have high risk of ESPs - which cause movement disorders
Parkinsomnia
Tremors
1st gens
Which are better for negative symptoms
2ng gen
Which cause weight gain more
2ng gen
Why does ESP occur
Blocking dopamine
Look at Parkinson’s there is too little dopamine
Do it can worsen Parkinson’s symptoms
What are some common symptoms of secondary gen
Weight gain
Hyperglycemia
Hyperlipidemia
QT prolongation
Hyperprolactinamia - breast enlargement
Hypotension
Thus what are the monitoring requirements
FBC, U&ES, LFTs
Blood glucose
Prolactins
Lipids
ECG
When should clozapine be used
When people don’t respond to 2 other antipsychotics
Which ADR is more common is clozapine
Agranulocytosis
