Secondary Hemostasis

Question 1

Formation of insoluble, cross-linked fibrin by activated coagulation factors, specifically thrombin

Answer 1

Secondary hemostasis

Question 2

Stabilized the primary platelet plug, particularly in larger blood vessels where the platelet plug is insufficient alone to stop hemorrhage

Answer 2

fibrin

Question 3

secondary hemostasis is synonymous to

Answer 3

coagulation

Question 4

Components of the secondary hemostasis

Answer 4

Cells
Enzymatic and non enzymatic coagulation factors
Protein substrates
Calcium
Phospholipid (Phosphotidylserine) membranes

Question 5

Coagulation factors can be what kind of proteolytic enzymes?

Answer 5

zymogens

Question 6

Substrates for enzymatic coagulation factors

Answer 6

enzymatic and non enzymatic coagulation factors

Question 7

two initial pathways which lead to fibrin formation

Answer 7

contact activation pathway (intrinsic)
tissue factor pathway (extrinsic)

Question 8

When two pathway will meet

Answer 8

common pathway

Question 9

4 phases

Answer 9

contact phase
activation of factor x
conversion of prothrombin to thrombin
formation of fibrin clot

Question 10

Fletcher factor

Answer 10

Prekallikrein

Question 11

High molecular weight kininogen (HMWK)

Answer 11

fitzgerald factor

Question 12

Plasma thromboplastin antecedent

Answer 12

Factor XI

Question 13

Christmas factor

Answer 13

IX

Question 14

Proccelerin/Labile Factor

Answer 14

V

Question 15

Hagenman Factor, Contact Factor

Answer 15

XII

Question 16

Calcium (factor)

Answer 16

IV

Question 17

Antihemophilic factor A

Answer 17

VII

Question 18

Stuart Factor

Answer 18

X

Question 19

Enzymes/zymogen

Answer 19

II, VII, IX, X, XI, XII, XIII, Prekallikrein

Question 20

Cofactors

Answer 20

III, V/Va, VIII/VIIIa, HMWK

Question 21

Vitamin dependent

Answer 21

II, VII, IX, X

Question 22

Factor XII will activate when in contact with

Answer 22

a negative charged surface (such as collagen)

Question 23

Activated Factor XII converts

Answer 23

Prekallikrein to kallikrein

Question 24

XIIa activates

Answer 24

Factor XI

Question 25

Factor XIa will activate Factor IX in the presence of

Answer 25

calcium

Question 26

Factor IXa activates Factor X in the presence of

Answer 26

Factor VIII Platelet phospholipid Calcium

Question 27

All cells, with exception to those in the blood, contain what factor

Answer 27

Tissue factor (Factor III)

Question 28

Released when injury occurs and acts as a cofactor in initiating coagulation

Answer 28

Tissue factor

Question 29

In the extrinsic pathway, Factor ___ binds with Factor ___and in the presence of calcium will activate Factor ___

Answer 29

VII, III, X

Question 30

Factor Xa with Factor V, platelet phospholipid, and calcium will activate

Answer 30

Factor II into Factor IIa (thrombin)

Question 31

Factor IIa convert

Answer 31

Fibrinogen to fibrin

Question 32

Factor IIa in the presence of calcium will activate

Answer 32

Factor XIII

Question 33

Stabilizes the clot

Answer 33

Factor XIIIa in the presenc eof calcium

Question 34

Stable fibrin clot in the presence of activated platelets will result to

Answer 34

retracted clot

Question 35

Inhibitors to coagulation

Answer 35

Protein C Protein S Antithrombin III Heparin cofactor II a2 macroglobulin extrinsic pathway inhibitor c1 inhibitor a1 antitrypsin

Question 36

Inhibitor of tissue factor

Answer 36

tissue factor pathway inhibitor (TFPI)

Question 37

Inhibitor of Factor II andX

Answer 37

antithrombin

Question 38

Inhibitor of factor v and viii

Answer 38

protein c protein s

Question 39

Inhibitor of fibrin

Answer 39

thrombin activatable fibrinolysis inhibitor (TAFI)