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HEMATOLOGY 2 LEC > SECONDARY HEMOSTASIS PART 1 > Flashcards

SECONDARY HEMOSTASIS PART 1 Flashcards

(60 cards)

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1
Q

What processes are essential in the secondary hemostasis

A

Coagulation cascade
Fibrinolysis

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2
Q

What are the 4 components of secondary hemostasis

A

Zymogens
Co-factors
Fibrinogen substrate
Control proteins

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3
Q

Zymogens

A

Prekallikrein
Prothrombin
VII
IX
X
XI
XII
XIII

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4
Q

Co-factors

A

HMWK
Tissue factor
Thrombomodulin
V
VIII
protein c
Protein s

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5
Q

Control proteins

A

Antithrombin
Heparin cofactor II
TFPI
ZPI
Protein c
A2 macroglobulin
A1 antitrypsin

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6
Q

what will happen if the fibrin clot is not stable

A

it will dissolve quickly

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7
Q

Factor 4

A

Calcium

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8
Q

I

A

Fibrinogen

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9
Q

II

A

Prothrombin

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10
Q

III

A

Tissue factor

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11
Q

IV

A

Calcium

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12
Q

V

A

Proaccelerin

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13
Q

VII

A

Proconvertin

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14
Q

VIII

A

Antihemophilic factor

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15
Q

IX

A

Plasma thromboplastin component

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16
Q

X

A

Stuart-prower factor

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17
Q

XI

A

Plasma thromboplastin antecedent

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18
Q

XII

A

Hageman factor

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19
Q

XIII

A

Fibrin stabilizing factor

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20
Q
  • first group of coagulation factor
  • belongs to zymogens under normal circumstance
  • enzymes that stabilizes protease
  • in the presence of stimulus they will be active
  • once activated may small letter a after sa roman numeral
A

Serine protease

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21
Q

What is the substrate of the inactive zymogen prothrombin

A

Fibrinogen
V
VIII
XI
XIII

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22
Q

What is the substrate of the inactive zymogen IX

A

X

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23
Q

What is the substrate of the inactive zymogen X

A

Prothrombin

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24
Q

What is the substrate of the inactive zymogen XI

A

IX

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25
What is the substrate of the inactive zymogen XII
XI
26
What is the substrate of the inactive zymogen prekallikrein
XI
27
Active protease of prothrombin and prekallikrein
Thrombin Kallikrein
28
This group is consumed to complete a clot formation
Procoagulant group
29
What are the needed participatory factors under procoagulant group in order to the entire cascade to occur
Phospholipids Ionized calcium (Fibrinogen)
30
What is the substrate of the inactive zymogen factor VII
IX X
31
What co-factors ang may function na procoagulant
Tissue factor V VIII high molecular weight kininogen
32
What co-factors ang may function na control
Thrombomodulin Protein s Protein z
33
- transmembrane receptor - extravascular cells surrounding ecs - vessel injury exposes tf
Tissue factor (FIII)
34
- antihemophilic factors - soluble plasma proteins
FV FVIII
35
Cofactor in prothrombinase complex
FVa
36
Cofactor in intrinsic tenase complex
FVIII
37
- cofactor in the contact factor complex - activates intrinsic pathway
HMWK (FITZGERALD FACTOR)
38
- Cofactor in fibrinolysis and protein c pathway - transmembrane protein on ecs
Thrombomodulin
39
Components of extrinsic tenase
VIIa Tissue factor Phospholipids Calcium
40
Components of intrinsic tenase
IXa VIIIa Phospholipids Calcium
41
Components of prothrombinase
Va Xa Phospholipids Calcium
42
Factor/s na gina activate sa extrinsic tenase
IX X
43
What are the coagulation complexes
Extrinsic tenase Intrinsic tenase Prothrombinase
44
Factor/s na gina activate sa intrinsic tenase
X
45
Factor/s na gina activate sa prothrombinase
Prothrombin
46
Vitamin k is synthesized in what organ
Liver
47
Vitamin k dependent procoagulants
FII FVII FIX FX
48
Vitamin k dependent regulatory proteins
Protein s Protein c Protein z
49
What will happen if there is vitamin k deficiency?
It will produce pivka factors and it cannot bind to phospholipids and calcium therefore there will be no plt activation
50
Thrombin functions
Fibrin formation Platelet activation Controls fibrinolysis Regulation of coagulation activation
51
unsa na factors ang naa sa plt activation
V VIII XI XIII
52
The prothrombin group/vit. K dependent group can be adsorbed by what reagent
Barium sulfate
53
Contact factors
HMWK PREKALLIKREIN FVII
54
Contact factor is activated by
Negative charged foreign surface Non-siliconated glass Ellagic acid Kaolin
55
- activates the intrinsic pathway - generates pro inflammatory products (bradykinin) - activates the complement system - activates, regulates fibrinolysis
Contact factors
56
Fibrinogen group
I V VIII XIII
57
Fibrinogen group factors na activated by cold temperature
VII XI
58
Vwf is produced by what cell
Weibel-palade bodies
59
Most sensitive for vitamin k
FVII
60
FVIII is produced by what cell
Endothelial cells

HEMATOLOGY 2 LEC (9 decks)

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