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SEE review Horvath > SEE 5 > Flashcards

SEE 5 Flashcards

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1
Q

___ LA’s are eliminated by plasma pseudocholinesterase except ___, which is eliminated hepatic

A

ester , cocaine

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2
Q

which LA class has greatest allergic potential

A

ester (from PABA)

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3
Q

____ is hydrolyzed much more slowly by plasma cholinesterase and is highly protein bound

A

tetracaine - therefore its the most toxic

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4
Q

what is the least potent ester

A

procaine

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5
Q

what is the max dose of cocaine

A

1.5mg/kg

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6
Q

____ LA’s are metabolized hepatic

A

amide

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7
Q

which LA causes etidocaine at a lower plasma concentration

A

etidocaine

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8
Q

what does EMLA cream contain

A

2.5 lido, 2.5 prilo

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9
Q

which LA may cause methemoglobinina

A

benzocaine

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10
Q

sensitivity testing:

A

SNO (sensitivity, negative, out)

SPI (Specificity, positive, in)

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11
Q

more soluble agents have a ____ inhalation induction

A

slower

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12
Q

less soluble agents have a ___ inhalation induction

A

faster

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13
Q

what do volatiles do to CBF and CMRO2

A

inc CBF, reduce CMRO2 (think they inc flow and reduce demand)

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14
Q

vapor pressure of a liquid is dec solely on

A

TEMP

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15
Q

which NMBs have histamine release

A

succs, miv, atra

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16
Q

roc & vec metabolism

A

primary biliary, secondary renal

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17
Q

brain uptake of anesthetics depends on what 4 things

A

blood solubility, CO, alveolar ventilation, inspired concentration

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18
Q

three ways to increase speed of equilibrium

A

inc inspired anesthetic concentration, second gas effect, inc alveolar ventilation

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19
Q

what are the two most important factors for increased alveolar partial pressure

A

inspired concentration and blood solubility

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20
Q

barbs are contraindicated in what two situations

A

status asthmatics and porphyria

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21
Q

how is propofol metabolized

Study These Flashcards
A

liver 70%, lung 30%

22
Q

what does etomidate do neuro wise

Study These Flashcards
A

dec CBF, ICP , CMRO2

23
Q

ketamine produces broncho_____

24
Q

rank the potencies of the opiates

Study These Flashcards
A

sufent > remifent > fent > alfent > MSO4 > meperidine

25
which NMB's use hoffman elimination
cis and atra
26
hoffman elimination is slowed by what two things
acidosis or dec temp
27
4 MR's that use renal excretion least
succs, atra, cis, miv
28
3 NDMR's not sifnificantly excreted renal
atra, cisatra, miv
29
what augments NMB? ____mag, ____calc, ____kalemia, ___thermia
hypermag, hypocalc, hypokalemia, hyperthermia
30
whats the earliest sign of MH
inc ETCO2
31
whats the standard diagnostic test for MH
halothane-caffeine contracture test
32
whats the dosing of dantrolene``
2.5mg/kg followed by 1-2mg/kg boluses to a max dose of 10mg/kg
33
what is the cardinal sign of NMS
fever
34
which 2 anticholinergics cross the BBB
atropine and scop
35
which age group has the highest MAC
6mo-12mo
36
factors that dec mac: age? temp? etoh? alpha2,
old, cold, acute etoh, depressants, alpha2's like clonidine, dec levels of CNS neurotransmitters
37
what does pregnancy do to MAC
dec
38
what 3 factors increase MAC
hyperthermia, hypernatremia, inc levels of CNS neurotransmitters
39
acceptable levels of N20 in the OR =
25ppm
40
acceptable levels of N20 + volatiles?
0.5ppm
41
acceptable level of volatile alone in the OR?
2ppm
42
n20 is metabolized to N2 in the intestine by ____
reductive anaerobic metabolism
43
what does n20 do to PVR
increases
44
what does N20 do to CBF and CMRO2
increases
45
what do volatiles do to the renal system
dec RBF, GFR, UO
46
____ is most degraded by soda lime and ____ least
sevo , des
47
whats the diff between competitive and non-competitive?
competitive can be overcome by increased concentrations of an agonist, while non-competitive cant be overcome by inc conc
48
ASA, dilantin, are examples of ___ order kinetics
zero. constant AMOUNT of a drug over time
49
first order kinetics : constant _____ eliminated per time
FRACTION
50
T/F barbiturates, opioids, benzos, amides, TCAs, antihistamines are all metabolized by CYP450
true

SEE review Horvath (10 decks)

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