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Flashcards in Selective toxicity mechanisms Deck (12):
1

how can drugs be organ specific

-the organ possesses physiological and anatomical attributes - possession of cell-specific metabolic and transport processes

2

what is the triple whanny

combination of a diuretic, ACE inhibitor and an NSAID --> can lead to acute renal failure

3

what enzyme does methotrexate resemble

dihydrofolate reductase

3

how does the structure of the nephron lead to relative hypoxia in the medulla

because the structure leads to a situation where oxygen can pass from arterial to venous side of the circulation (counter-current exchange) - lowering oxygen concentration in the renal medulla

5

what is the difference in action of methotrexate in low and large doses

lower doses - cytotoxic immunosuppressant higher doses - cytotoxic anticancer agent

6

methotrexate resembles

folic acid

7

what enzyme does trimethorprim inhibit

dihydrofolate reductase

8

the action of sulfanilamide relies on the fact that it resembles

folic acid (precursor of DNA)

9

how does the triple whammy lead to acute renal failure

because of the prostaglandin-mediated vasodilation that preserving renal blood flow being inhibited

10

what are the levels in which a drug can be selective

species level cell level organ level

11

toxicity of gentamycin and other aminoglycosides

nephrotoxicity - in people with prolonged exposure (generally reversible) ototoxicity - less frequent - deafness and/or vertigo (generally permanent)

12

Which enzyme does sulfanilamide inhibit

dihydropteroate synthase