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Flashcards in Sensory systems 2 Deck (14)
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1
Q

What do A delta fibres and c fibes detect

A

ADelta- thermal, mechanical stim

C- dull pain, unmyleanated

2
Q

What is hyperalgesia and what does it causes/what causes it

A

Hyperalgesia occurs when tissue damage occurs and several chem mediators (histamine, bradykinins, Atp released) sensitizes area

3
Q

What is Substance P

A

-Released w tissue damage

Sensitizes pain receptors and increases vasodialation to injured region (increases input of chem mediators)

4
Q

What does NGF do

A

When released in tissue damage response it acts as a pain mediator (enhances perception of pain)

5
Q

Which rexxed lamina will pain typicall go into

A

Specifically rexxed lamina 1 + 4 + 5

6
Q

What rexed lamina does the spinoreticular tract enter and what does it do

A

Recieves pain info that projects into lamina 7+8 and up to thalmus

Provides more autonomic response to pain (emotional etc)

7
Q

why does refered pain occur

A

Viscera project to same a + c fibres and both project to cortex (cant tell dif)

Pain travels back along autonomic neurons to specific levels

8
Q

What brain regions attempt to modulate pain

A

Venterobasilar complex of thamus

  • internal capsul
  • periaquaductal + periventricular grey
9
Q

Where do opiots have a great affect in the CNS

A

Dorsal horn has high density

=decreases release of NT and neuromodulators +decrease calcium to terminals ( prevents docking)

10
Q

How does TENS work (and how long till it takes affect)

A

20 mins min

Stims a alpha and beta fibres which stims inhibitoru interneurons (closes gate)

11
Q

What part of brain has a big impact of pain + fear and what receptors does it have that can be blocked

A

Ant cingulate cortex (which communictes w amygdala and limbic system)

-Has NMDA receptors (which if blocked may block emotional tag to pain.)

12
Q

What are some characteristics of someone with chronic pain

A
  • Burning/shooting pain
  • Summation- progressive worseing by slow repetatie stim
  • Hyperalgesia- increased response to painful stim
  • allodynia- pain to normally non painful stim
13
Q

What are some aspects that change in chronic pain (3)

A
  1. Overly actie dorsal horn neurons
  2. NMDA and AMPA receptors are phosphorylated (lose ability to inhibit pain)
  3. Inability to block signals (GABA input diminishes)
14
Q

What is nociplastic pain

A

Pain that arises from altered nociception despite no clear evidence of actual or thretend tissue damage