Sepsis Flashcards
1
Q
How do you define septic shock?
A
Sepsis and SBP <60
2
Q
What are causes of SIRS? (non infectious)
A
Tissue damage (organ damage/ischemia)
Immune rxn (lupus, anaphylaxis)
Exogenous tissue damage (burns)
Miscellaneous (thyroid storm)
3
Q
What are the main cytokine mediators of sepsis?
A
TNF-a
IL-1
4
Q
What are the major signs of sepsis?
A
- hypotension
- purpura fulminant
- hypoperfusion
- acute respiratory distress syndrome
5
Q
What are the major maladaptive responses in sepsis?
A
- blood vessels dilate
- blood vessels leaking
- cytokine storm
- sympathetic storm (epinephrine)
6
Q
How do you treat sepsis?
A
- Treat original infection/nidus
- IVF/vasopressors like epinephrine and vasopressin
- ICU
- glucose
- ventilator
