Session 11 - Drugs Affecting Acid Secretion

Question 1

What are the main types of drugs used to treat peptic disorders?

Answer 1

Antacids
Alginates
Histamine 2 receptor antagonists (H2RA)
Proton pump inhibitors (PPI)

Question 2

Give examples of H2 receptor antagonist.

Answer 2

Cimetidine
Ranitidine
Nizatidine
Famotidine

Question 3

Give examples of PPIs.

Answer 3

Omeprazole
Lansoprazole
Rabeprazol 
Pantoprazole 
Esomeprazole

Question 4

What is a possible side effect of PPIs?

Answer 4

Diarrhoea

Question 5

What are the principles of treatment for GORD?

Answer 5

Symptom control and healing of oesophagitis.

Involves:
Lifestyle 
Antacids/alginates
H2RA
PPI

Possibly do anti-reflux surgery

Question 6

What treatment is given for peptic ulcers?

Answer 6

Stop NSAIDs
Give H2RA/PPI for 6 weeks
H pylori eradication

Question 7

How is H pylori eradicated?

Answer 7

2 antibiotics and full acid blockade using PPI, (e.g. give clarithromycin, amoxycillin and lansoprazole)