Session 5: Synaptic Transmission Flashcards Preview

Sem 1: Pharamacology and Physiology > Session 5: Synaptic Transmission > Flashcards

Flashcards in Session 5: Synaptic Transmission Deck (14):
1

Define neuromuscular junction.

The synapse between a nerve and a skeletal muscle fibre.

2

Why can the internal concentration of calcium in the pre-synaptic knob be raised so significantly?

The concentration of calcium inside the pre-synaptic knob is so low (1x10^-7M)

3

How can you increase the amount of neurotransmitter released?

Increase the frequency of AP

4

Describe the molecular chemistry of a calcium channel.

- 1 subunit (4 alpha helix units)
- S4 voltage sensor region (high positive density)
- Pore

5

What enzyme is required to break down ACh?

Acetylcholine esterase

6

What happens after the neurotransmitter is brought close to the post-synaptic knob?

A snare complex forms making a fusion pore

7

Name the 2 types of nicotinic ACh receptor blockers

1. Depolarising blockers
2. competitive blocker

8

Give an example of a competitive blocker

Tubocurarine (d-TC)

9

Give an example of a depolarising blocker

Succinylcholine

10

How can the affects of Tubocurarine (d-TC) be overcome?

Increase the concentration of ACh

11

Name an autoimmune disease which targets nACh receptors.

Mayasthenia gravis

12

What is Mayasthenia gravis?

Patients suffer profound weakness as nAChR is degraded by antibodies meaning the end-plate potential fails to reach threshold.

13

What type of channel is nAChR?

LGIC

14

What is the difference between nAChR and mAChR?

nAChR- LGIC
mAChR- coupled to G-proteins