Flashcards in Session 5: Synaptic Transmission Deck (14):
Define neuromuscular junction.
The synapse between a nerve and a skeletal muscle fibre.
Why can the internal concentration of calcium in the pre-synaptic knob be raised so significantly?
The concentration of calcium inside the pre-synaptic knob is so low (1x10^-7M)
How can you increase the amount of neurotransmitter released?
Increase the frequency of AP
Describe the molecular chemistry of a calcium channel.
- 1 subunit (4 alpha helix units)
- S4 voltage sensor region (high positive density)
What enzyme is required to break down ACh?
What happens after the neurotransmitter is brought close to the post-synaptic knob?
A snare complex forms making a fusion pore
Name the 2 types of nicotinic ACh receptor blockers
1. Depolarising blockers
2. competitive blocker
Give an example of a competitive blocker
Give an example of a depolarising blocker
How can the affects of Tubocurarine (d-TC) be overcome?
Increase the concentration of ACh
Name an autoimmune disease which targets nACh receptors.
What is Mayasthenia gravis?
Patients suffer profound weakness as nAChR is degraded by antibodies meaning the end-plate potential fails to reach threshold.
What type of channel is nAChR?