Shikimate Pathway Flashcards

(46 cards)

0
Q

Building block of shikimate pathway

A

C6C3 phenylpropane unit

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1
Q

Central intermediate in shikimate pathway

A

Shikimic acid

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2
Q

Building block for alkaloidal structures

A

L-Trp

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3
Q

Precursors of L-DOPA and DOPAchrome

A

L-Phe and L-Tyr

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4
Q

Precursor of catecholamines

A

L-dopa

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5
Q

Precursor of melanin

A

Dopachrome

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6
Q

Precursor of tannins

A

Gallic acid

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7
Q

Plant polyphenols which has the ability to precipitate proteins

A

Tannins

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8
Q

Botanical origin of witch hazel leaves

A

Hamamelis virginiana

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9
Q

Botanical origin of nutgall

A

Rhus chinensis

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10
Q

Botanical origin of mangrove

A

Rhizophora mangle

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11
Q

Color formed upon rxn with ferric salts

A

Dark blue (H) to greenish black (NH)

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12
Q

Color formed upon rxn with potassium ferricyanide and ammonia

A

Deep red

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13
Q

Types of tannins

A

Hydrolyzable and non-hydrolyzable

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14
Q

Other name for hydrolyzable tannins

A

Pyrogallotannins

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15
Q

Intermediate where pyrogallotannins are derived

A

Dehydroshikimic acid

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16
Q

Classes of hydrolyzable tannins

A

Gallotannins and ellagitannins

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17
Q

Esters of gallic acid with polyalcohol typically glucose

A

Gallotannins

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18
Q

Hexahydroxydiphenic acid esters by oxidative coupling of neighboring gallic units attached to D-glucose

A

Ellagitannins

19
Q

Gallotannins arise from ?

20
Q

Other names for non-hydrolyzable tannins

A

Condensed tannins, proanthocyanidins, pycnogenols, leucoanthocyanidins

21
Q

Non-hydrolyzable are derived from ?

A

Flavonoid precursors

22
Q

Product of polymerization of nonhydrolyzable tannins

23
Q

Test for total tannin analysis

A

Goldbeater’s skin test/Heme analysis

24
Color of spot of tannins in short UV light
Dark purple
25
Color formed upon rxn with Folin-Ciocalteu reagents
Blue spots
26
Color formed upon reaction of tannins with NH3 vapor
Blue to gray spot
27
Uses of tannins
Leather industry, antidote for alkaloidal poisoning, astringent, ink industry
28
Most permanent black ink made by mixing iron salt with gallic acid and tannin in water to form ferous tannate
Iron-gall ink
29
Formed when little ferrous tannate ink dries
Black insoluble ferric tannate
30
Other names for folic acid
Folacin, pteroylglutamic acid, vit B9
31
Conjugate of pteridine deriv, PABA, and glutamic acid
Folic acid
32
Folic acid deficiency
Megaloblastic anemia
33
Functions via a series of folate coenzymes as a carrier of one-carbon groups which are involved in amino acid and nucleotide metab
Tetrahydrofolic acid
34
Folic acid inhibitors
Sulfanilamide and other antibacterial sulpha drugs, trimethoprim, pyrimethamine, methotrexate
35
Inhibit dihydropteroate synthase
Sulfanilamide and other antibacterial sulpha drugs
36
Enzyme incorporating PABA
Dihydropteroate synthase
37
Antibacterial; Inhibit dihydrofolate reductase
Trimethoprim
38
Antimalarial; inhibit dihydrofolate reductase
Pyrimethamine
39
Blocks or prevents DNA methylation; blocks pyrimidine biosynthesis
Methotrexate
40
Counteract folate-antagonist action of anticancer agent
N5-formyl-tetrahydrofolic acid or folinic acid or leucovorin
41
Isolated from Streptomyces venezuelae; one of first broad spectrum antibiotics; can cause blood disorders
Chloramphenicol
42
Enzyme that catalyzes peptide bond formation
Peptidyl transferase
43
Shikimic acid is synthesis blah blah of antiviral what
Oseltamivir
44
Inhibitor of EPSP synthase
Glyphosate
45
MOA of chloramphenicol
Block peptidyl transferase