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Pharm II > SHIT I CANT FUCKING REMEMBER > Flashcards

SHIT I CANT FUCKING REMEMBER Flashcards

1
Q

What diuretics are good for . reduced GFR?

A

Loops

Metolazone (thiazide)

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2
Q

What drug should you not use with K sparing diuretics?

A

ACEI/ARBs (both cause hyperkalcemia)

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3
Q

What drugs should you not use in pts with acute renal failure with renal a. stenosis?

A

ACEI/ARBs

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4
Q

What are the contraindications of B blockers?

A 
End stage HF
Diabetes
Heart block (CCB)
Asthma
Variant angina (not effective)

(inhibit renin release)

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5
Q

What drugs increase digoxin toxicity?

A

Hypokalemia action (thiazide/loops)
Further ↓ SA/AV node activity (B-blockers)
Myocardial sensitization to digoxin
(NE-releasing agents)

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6
Q

What drug decrease the effectiveness of digoxin?

A

CCB

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7
Q

Sudden withdraw of what drug can lead to HTN crisis?

A

Clonidine

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8
Q

What drug inhibits clonidine?

A

TCA

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9
Q

What are the SE of Clonidine and methylodopa?

A

CNS effects (sedation) Xerostomia (dry mouth)

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10
Q

What are the SE of methylodopa?

A

Hemolytic anemia
Hepatotoxicity
Prolactin secretion

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11
Q

What drug is associated with 1st dose phenomenon?

A

Prazosin

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12
Q

What is a SE of lebetalol?

A

Hepatotoxic (why its only used in emergencies)

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13
Q

Reflex tachycardia, ↑ contractility
↑ Renin secretion Fluid retention
HA, flushing Palpitations, dizziness

Are effects of which drugs?

A

Vasodilators

Hydralazine, sodium nitroprusside, fenoldopam, CCB

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14
Q

What are SE of -dipines?

A

Enhanced development of MI

Gingival hyperplasia

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15
Q

What is a common SE of verapamil?

A

Constipation

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16
Q

What drug is associated with throbbin HA and exposure tolerance?

A

Nitroglycerin, Isosorbide dinitrate

17
Q

What is the only CA that is oral?

A

Acetazolamide

18
Q

What drugs are contraindicated in use with a PDE5 inhibitor?

A

Nitrates/nitrites
A-blockers
CYP3A4/2C9 inhibitors

19
Q

What are contraindications of . statins?

A

Pregnancy

Active hepatic disease Concurrent use with P450 activators or inhibitors

20
Q

What drug inhibits statins?

A

Gemfibrozil

21
Q

What drug can cause cyanide accumulation

A

Sodium nitroprusside

22
Q

What drug can be given in high dose for high risk ASCVD pts

A

Atorvastatin

23
Q

What are SE of statins?

A

↑ Aminotransferase –> Liver damage

↑ Creatine kinase –> Myopathy, muscle pain

24
Q

When should stains be given?

A

Evening

25
Q

What drug can interfere with warfarin therapy due to its ability to cause hypoprothrombinemia from vit K malabsorption?

A

Cholestyramine

26
Q

What hyperlipidemia drug has no effect in familial hypercholesterolemia or hypertriglyceridemia? How should it be taken?

A

Cholestyramine

With meals

27
Q

What drug can cause cutaneous vasodilation? How can you prevent this?

A

Niacin

Aspirin

28
Q

What drug causes the following SE:
↑ Aminotransferase
↑ Cholelithiasis, gallstones Inhibits metabolism of statins May ↑ LDL

A

Gemfibrozil

29
Q

How are Alirocumab and Evolocumab administered?

A

monthly subcutaneous injections

30
Q

What are SE of Class IA durgs?

A 
Low therapeutic index
Cardiac toxicity
Blocks a receptors 
Torsade de pointes
Diarrhea
Cinchonism
31
Q

How is lidocaine administered and why is it only useful for ventricular arrhythmias?

A

“Window “current is only in Purkinje/ventricles

32
Q

What drug has Strong pro-arrhythmic effects?

A

Flecainide

33
Q

What drug has the following SE
Pulmonary fibrosis
Deposited in tissues, cornea (yellow brown), skin (gray blue)
Thyroid dysfunction

A

Amiodarone (oral, IV)

**Prolonged QT, but no torsade de pointes

34
Q

What drug will increase the effects of warfarin? decrease?

A

Increase- ASA

Decrease- Oral contraceptives

35
Q

What drugs are contraindiated in pts with DIC or GU bleeding?

A

Aminocaprotic acid Tranexamic acid

Anti-fibrinolytics

36
Q

What drugs should you avoid when taking Clopidogrel or Ticagrelor?

A

Drugs that impair CYP2C19 function (omeprazole)

Pharm II (10 decks)

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