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Hematologia 🩸 > Sindromes Mielodisplasicos > Flashcards

Sindromes Mielodisplasicos Flashcards

1
Q

Característica principal 🏆

A

Hematopoyesis inefectiva: displasia morfológica de células hematopoyeticas y citopenias periféricas

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2
Q

Edad media

A

71 años 👨🏻‍🦳

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3
Q

Incidencia aumenta con

A

Edad

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4
Q

Más afectados

A

Hombre 👨🏻

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5
Q

FR

A

Tabaquismo 🚬

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6
Q

10 se debe a

A

RT Y QT

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7
Q

Exposiciones laborales relaacionadas

A

Radiación
Benceno
Solventes orgánicos
Hule

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8
Q

Manifestaciones

A

Sx anémico
Tx hemorragicos por Trombocitopenia
Infecciones recurrentes

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9
Q

Hallazgos más frecuentes

A

Anemia
Trombocitopenia

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10
Q

Criterios mínimos para el dx

A

Citopenia (Hb<11, Neutrofilia <1500, plaquetas <100000
+
Blastos >5%
Cariotipo medular anormal
Displasia>10%

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11
Q

Medidas generales

A

Soporte transfusional (Hb<8.5 meta 10g/dl)
Quelacion del hierro
Antibióticos

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12
Q

Tx de riesgo menor

A

Agentes estimulantes de eritropoyesis inmunoglobulina de timocito
Lenalidomida
Azacitidina

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13
Q

Tx de riesgo mayor

A

Inhibidores de transfieras de metilo
Trasplantes de células troncales hematopoyeticas

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14
Q

Único tratamiento curativo

A

Trasplante de células troncales

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15
Q

Un tercio sufren transformación a

A

LMA

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16
Q

Riesgo menor supervivencia

A

3-7 años

17
Q

Riesgo mayor supervivencia

A

1-5 años

Hematologia 🩸 (27 decks)

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