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Top 100 Drugs (Pre-reg) > Skin > Flashcards

Flashcards in Skin Deck (8):

What are the indications for topical corticosteroids (glucocorticoids)?

Used in inflammatory skin conditions e.g. eczema, to treat disease flares or to control chronic disease where emollients alone are ineffective.


How do corticosteroids have their effects on skin?

Corticosteroids have immunosuppresant, metabolic and mineralcorticoid effects. Where they are applied topically, effects are mostly limited to the site of application.


What are the adverse effects of corticosteroids?

Adverse effects are uncommon with mild or moderately potent topical corticosteroids (hydrocortisone 0.1-2.5% is mild). However potent (betamethasone valerate 0.1% is potent) and very potent topical corticosteroids can cause local adverse effects such as skin thinning, striae (stretch marks), telangiectasia (Telangiectasia is a condition in which widened venules (tiny blood vessels) cause threadlike red lines or patterns on the skin) and contact dermatitis.


Half a finger tip unit is enough cream or ointment to cover what corresponding region of space?

one palm size


What are emollients used for?

Dry skin disorders, they work by replacing water content in dry skin.
They contain oils or paraffin-based products that help to soften the skin and can reduce water looss by protecting against evaporation from the skin surface.

Many can be used as a soap substitute (as soap is drying to the skin).


Why can emollients exacerbate acne vulgaris and folliculitis?

By blocking pores and hair follicles.


What is the main adverse effect of emollients?

They cause greasy skin but this is integral to their therapeutic effect.


What is the main risk of using parafin-based emollients where the oil content is high (>50%)?

They are a significant fire hazard and if accumulation into bedding or clothing occurs become a significant fire risk.