Soft Tissue 1

Question 1

The 4 gram (-) rod pathogens

Answer 1

P. aeruginosa, B. cepacia, B. pseudomallei, B. mallei

Question 2

P. aeuroginosa

Answer 2

Common and serious nosocomial pathogen

Question 3

B. cepacia

Answer 3

Serious in context of CF

Question 4

B. pseudomallei and B. mallei

Answer 4

Rare in U.S., but can be lethal

Question 5

Common Qualities of these Pathogens

Answer 5

Gram (-) aerobes, nonfermenters, oxidase (+), grow easily in culture

Question 6

Antibiotic resistant?

Answer 6

Yes, especially P. aeruginosa- through low permeability outer membrane and efflux pumps

Question 7

Which two have minimal growth requirements and often contaminate hospital solutions?

Answer 7

P. aeruiginosa and B. cepacia

Question 8

Community acquired presentations of P. aeruginosa

Answer 8

1) Endocarditis in IV drug addicts
2) Otitis externa in unchlorinated hot tubs
3) Osteochondritis in sneaker punctures
4) Corneal infections under contact lenses

Question 9

P. aeruginosa presentation

Answer 9

Hospital

Question 10

B. cepacia presentation

Answer 10

CF centers

Question 11

B. pseudomallei presentation

Answer 11

Previously ill travelers/immigrants or Vietnam veterans

Question 12

B. mallei

Answer 12

Previously ill travelers/immigrants with animal handling history

Question 13

How can they all present?

Answer 13

Septicemia/pneumonia with poor prognosis

Question 14

How to diagnose?

Answer 14

Culture and Gram stain

Question 15

How to treat?

Answer 15

Latest combo of antibiotics. Test Ab sensitivity before and during treatment