Soft Tissue 2 Flashcards
(20 cards)
Anaerobic infections usually follow…
Deep tissue trauma- accidents, cancer, surgery, immunosuppression, IV drug use
For which anaerobic infection is there a vaccine for?
Tetanus
Gram positive anaerobes?
Clostridia and actinomyces
Environmental anaerobic flora?
C. tetani and C. botulinum
Normal anaerobic flora?
C. difficile, Bacteriodes, Prevotella. and Actinomyces
Environmental and normal flora?
C. perfringens
C. tetani and C. botulinum pathogenicity?
Neurotoxin with protease activity at synaptobrevin II
C. tetani effects
tetanospasmin–> inhibitory CNS blocks release of GABA and glycine. Leads to spasm
C. botulinum effects
Works in periphery and blocks release of ach–> result is flaccid paralysis
Treatment for C. tetani and C. botulinum?
Antitoxin that binds and inactivates the neurotoxin
Where do we see C. tetani and C. botulinum infections?
Neonates, IV drug users, infected wounds, contaminated food
Gas gangrene
C. perfringens–> Treat ASAP
Tissue degrading enzymes produced by what
Bacteroides and Prevotella
How to ID C. perfringens and Bacteroides and Prevotella?
Anaerobic culture and gas chromatography
How to treat C. perfringens and Bacteroides and Prevotella?
Antibiotics and surgical care
Food Poisoning
C. perfringens–> production of entertoxin causing diarrhea and disrupting tight junctions
C. difficile
Pseudomembranous colitis after antibiotic use
Treat C. diff?
Change antibiotics and intervene surgically as necessary
Nodules containing pus with sulfur granules near mouth or colon?
Actinomyces
Treatment of actinomyces?
Penicillin and surgical care as necessary
