Specific Immunity Flashcards
(24 cards)
what is specificity?
the response is selective as only one molecule is able to trigger the response
what is the difference between humoral and cell mediated immunity?
humoral depends on antibodies yet for cell mediated the specificity depends on T cells
what is immunogenicity?
the ability to induce am immune response
what is antigenicity?
the ability to combine with products of the immune response such as antibodies
what are endogenous antigens recognised by?
Tc cells
what are exogenous antigens recognised by?
Th cells
what is a B cell receptor like?
same structure of the circulating antibody and also secretes antibodies
what is a T cell receptor like?
highly specific shaped receptor
how does chemical composition affect immunogenicity?
only synthetic copolymers are immunogenic
how does processing and presentation effect immunogenicity?
T cells need antigens present to them, better if insoluble
what is an epitope?
an antigenic determinant, the site on an antigen molecule where an antibody binds
how does the biological system of the person effect epitopes?
the genotype of recipient, dosage of immunogen, addition of adjuvant
what is a happen?
a molecule too small to initiate an immune response, needs carrier molecule
what response can happens initiate?
allergic reactions e.g. to penicillin
what is the definition of an antibody?
a protein that combines with the antigenic determinant that triggered its production
what are the heavy chains on an antibody?
muon, gamma, alpha, delta, epsilon
what are the light chains?
K and lambda
what is the Fc portion of the antibody?
the stem of the antibody
what are the features of the IgG antibody?
can cross the placenta, Y shaped, in blood/lymph/intestines
what are the features of IgA antibody?
monomers and dimers, in saliva/mucus/milk
what are the features of IgM antibodies?
pemtamers/monomers on B cells, first antibody after exposure
what are the features of IgD antibodies?
involved in activation of B cells, on B cells as antigen receptor
what are the features of IgE antibodies?
on mast cells and basophils, allergic reactions
what ways do antigen-antibody complexes eliminate antigens?
activate complement, opsonisation, neutralisation via cross linking toxin molecules
