Spinal Cord Flashcards

1
Q

Where does the spinal cord begin?

A

Foramen magnum

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2
Q

Where does the spinal cord end in adults?

A

L1 to L2

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3
Q

Where is the spinal cord located?

A

In the vertebral canal of the vertebral column

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4
Q

What are the functions of the spinal cord?

A

Sensory and motor innervation of the entire body inferior to head (via spinal nerves)

Two way condiction pathway between body and brain

Major centre for reflexes

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5
Q

Until what gestation does the spinal cord run the full length of the vertebral canal?

A

12 weeks gestation

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6
Q

What causes regression of spinal cord to L3/L2 by birth?

A

Rapid growth of vertebral canal - differential rates of growth

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7
Q

What is left at the caudal end of the vertebral canal due to the regression of the spinal cord during gestation?

A

Filum terminale

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8
Q

What is the filum terminale?

A

Fibrous tissue that is a continuation of pia mater

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9
Q

What is the function of the filum terminale?

A

Connects conus medullaris (caudal end of spinal cord) to coccyx

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10
Q

How many weeks post birth does the spinal cord reach L1/L2?

A

3 weeks post birth

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11
Q

What is the embryological cause of Spina Bifida?

A

Failure of vertebrae fusion in embryonic development

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12
Q

Which area of the spine does Spina Bifida usually occur?

A

Lumbosacral region

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13
Q

What are the four subtypes of Spina Bifida?

A

Occulta
Meningocele
Myelocele
Meningomyelocele

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14
Q

Where is the rostral end of the adult spinal cord?

A

Medulla oblongata

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15
Q

What is the caudal end of the adult spinal cord?

A

Conus medullaris

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16
Q

What is the cauda equina?

A

Collection of nerves at the caudal end of the spinal cord

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17
Q

At which vertebrae does the cauda equina emerge?

A

L3/L2

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18
Q

How many spinal nerves are there?

A

31 spinal nerve pairs

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19
Q

Which vertebrae do the nerve roots from the cauda equina emerge from?

A

L3 - S5

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20
Q

Which cistern is the conus medullaris located in?

A

Lumbar cistern

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21
Q

What are the meningeal layers of the spinal cord?

A

Pia

Arachnoid

Dura

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22
Q

What are the three potential spaces in the spinal cord meninges?

A

Epidural (outside the dura)

Subdural (between dura and arachnoid)

Subarachnoid

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23
Q

What is the denticulate ligament?

A

Anchors the dura mater to the pia mater

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24
Q

What is the spinal dura surrounded by?

A

Extradural venous plexus

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25
Q

What does the extradural venous plexus do?

A

Drains red marrow of spine

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26
Q

How does the extradural venous plexus facilitate metastasis of malignancies?

A

The plexus lacks valves, allows malignant cells to spread easily

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27
Q

What are the two spinal enlargements?

A

Cervical enlargement (brachial plexus)

Lumbar enlargement (lumbo-sacral plexus)

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28
Q

What does the brachial plexus innervate?

A

Upper extremities

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29
Q

How many cervical spinal nerves are there?

A

8

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30
Q

How many thoracic spinal nerves are there?

A

12

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31
Q

How many lumbar spinal nerves are there?

A

5

32
Q

How many sacral spinal nerves are there?

A

5

33
Q

How many coccygeal spinal nerves are there?

A

1

34
Q

Where do the spinal nerves lay in the vertebral column?

A

Intervertebral foramina

35
Q

What forms the intervertebral foramina?

A

Space between the spinal pedicles

36
Q

How is the spinal cord protected?

A

Bone - vertebral canal

Ligaments - attach adjacent vertebrae to each other and anchors dura mater

Epidural fat - acts as a cushion

Meninges - act as a buffer

37
Q

Where is CSF located in the spine?

A

Subarachnoid space

38
Q

What is a lumbar puncture?

A

Procedure performed where a needle is inserted in the subarachnoid space to collect CSF

39
Q

Why might a lumbar puncture be performed?

A

Control CSF pressure (e.g. intracranial hypertension)

Detect CSF pressure

Deliver anesthetic

Evaluate CSF for infections and inflammatory conditions

40
Q

What position must the spine be in for a lumbar puncture and why is this position important?

A

Must be flexed so the needle can pass between spinal processes

41
Q

Between which vertebrae are lumbar punctures usually performed?

A

L3-L5

42
Q

What is at the centre of the spinal cord?

A

Hollow central canal

43
Q

Which type of matter surrounds the central canal?

A

Grey matter

44
Q

Where is white matter located in the spinal cord?

A

Around the grey matter

45
Q

What is the white matter of the spinal cord composed of?

A

Ascending and descending axon tracts

46
Q

What is in the dorsal horn of the spinal cord?

A

Cell bodies of sensory interneurons

47
Q

What is in the ventral horn of the spinal cord?

A

Cell bodies of motor neurons

48
Q

Which is the ‘thicker’ horn on a diagram of a coronal section of spinal cord?

A

Anterior horn

49
Q

How are Rexed’s laminae of the grey matter of the spinal cord divided?

A

Based on cytoarchitecture

50
Q

What are laminae 1 to 3 of the spinal cord known as?

A

Substantia gelatinosa

51
Q

What is the substantia gelatinosa involved in?

A

Nociception

52
Q

What medications work on the substantia gelatinosa?

A

Opiates

53
Q

What information do the ascending fibers of the spinal cord carry?

A

Sensory information from body to brain

54
Q

What information do descending fibers of the spinal cord carry?

A

Motor instructions from brain to spinal cord to stimulate muscle contraction or secretion from glands

55
Q

What do commissural fibres of the spinal cord do?

A

Cross from one side of the spinal cord to the other

56
Q

What are three major ascending pathways for somatic sensory information in the spinal cord?

A

Dorsal column pathways

Spinocerebellar

Spinothalamic

57
Q

What are the two types of descending pathways for motor information in the spinal cord?

A

Pyramidal

Extrapyramidal

58
Q

Which two of the three major ascending pathways in the spinal cord decussate?

A

Dorsal column - medial lemniscus

Spinothalamic

59
Q

Which major ascending pathway in the spinal cord is ipsilateral and does not decussate?

A

Spinocerebellar

60
Q

What information does the spinocerebellar ascending pathway provide and where does it project to?

A

Proprioception from skeletal muscles
Projects to cerebellum

61
Q

What information does the dorsal column medial lemniscus ascending pathway provide and where does it project to?

A

Discriminative touch sensation
Projects through the thalamus to the somatosensory cortex

62
Q

What information does the spinothalamic ascending pathway provide and where does it project to?

A

Nondiscriminate sensations such as pain, temp, and pressure
Projects through the thalamus to the somatosensory cortex

63
Q

Where does the medial lemniscus pathway decussate?

A

Medulla

64
Q

Where does the spinothalamic pathway decussate?

A

Spinal cord

65
Q

Which ascending pathway decussates in the medulla oblongata?

A

Medial lemniscus pathway

66
Q

Which ascending pathway decussates in the spinal cord?

A

Spinothalamic pathway

67
Q

Which ascending pathway is involved with proprioception?

A

Spinocerebellar

68
Q

Which ascending pathway is involved with discriminative touch?

A

Medial lemniscus

69
Q

Which ascending pathway is involved with non-discriminative touch?

A

Spinothalamic

70
Q

What is an example of pyramidal descending tracts in the spinal cord?

A

Lateral corticospinal

71
Q

What information does the lateral corticospinal pathway provide?

A

Voluntary movement to limb muscles

72
Q

What information does the ventral corticospinal pathway provide?

A

Voluntary movement to axial muscles

73
Q

Which descending tract decussates in the pyramids of the medulla?

A

Lateral corticospinal

74
Q

Which descending tract decussates in the spinal cord?

A

Ventral corticospinal

75
Q

Which corticospinal descending tract is extrapyramidal?

A

Ventral corticospinal