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AM- STEP1 > STEP1 > Flashcards

STEP1 Flashcards

1
Q

Lead poisoning causes (3)

A

Disrupt hemoglobin synthesis

Neurotoxicity

Anemia

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2
Q

Lead poisoning inhibits (2)

A

delta- aminolevulinic acid dehydratase
Ferrochelatase

Important in heme synthesis

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3
Q

Lead poisoning can cause degradation of

A

rRNA in RBC and can lead to basophilic stippling

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4
Q

Tx medications for lead poisoning (3)

A

Dimercptosuccinic (DMSA)
Dimercaprol
CaEDTA

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5
Q

Most abundant type of RNA

A

rRNA

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6
Q

Start codon

A

AUG

Methionine

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7
Q

STOP codon

A

UGA
UAA
UAG

Nonsense mutation

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8
Q

Enzyme that breaksdown lactose

A

Beta-galactosidase

Breaks down into glucose and galactose

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9
Q

Two things needs to breakdown of lactose

A

CAP (catabolite activating protein)

  • Have to have for transcription b-galactosidase
  • only present w/ absent glucose

Lac repressor protein

  • alway bound unless lactose present
  • allolactase binds repressor changes its shape prevents from binding DNA
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10
Q

RNA polymerase I produces
RNA polymerase II
RNA polymerase III

A

rRNA

mRNA

tRNA

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11
Q

alpha-amanitinin

A

mushroom toxin
inhibits RNA polymerase II
Hepatotoxicity, liver failure

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12
Q

Rifampin

A

4Rs
Inhibits RNA polymerase
Red secretions
RRRRRevs up cytochrome P450

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13
Q

5’ cap provided by

A

S-adenosyl-methionine (SAM)

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14
Q

Splices out introns

A

Splicisome

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15
Q

Creates tail w/o DNA template for 3’ end

A

Poly-A polymerase

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16
Q

Specific signal to get started of 3’ end

A

AAUAA

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17
Q

Shoulder muscles movements (4 muscles)

A

Supraspinatus: First 15 degree of abduction

Subscapularis: IR

Infraspinalus: ER

Terres minor: ER, transverse abduction, extension

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18
Q

Suprascapular N.

A

Supraspinatus

Infraspinatus

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19
Q

Axillary N.

A

Teres minor

Deltoid

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20
Q

Upper and Lower subscapular N.

A

Subscapularis

21
Q

Drugs not to use w/ G6PD def

A

Sulfonamide drugs

22
Q

Vit K for synthesis of what coagulation factors

A

K is for koagulation

II, VII, IX, X
Protein C and S

Warfarin inhibits

23
Q

Vit K is essential cofactor for what enzyme

A

gamma-glutamyl carboxylase

24
Q

Black urine and dark spots in eyes

A

alkaptouria

Def of homogentisic acid oxidase

25
Q

Maple syrup urine disease deficiency

A

Branched chain alpha-ketoacid dehydrogenase complex

26
Q

Homocystinuria cause by deficiency in

A

Cystathionine synthase

27
Q

PKU deficiency in

A

Phenylalanine hydroxylase

28
Q

Albinism due to deficiency in

A

tyrosinase (one cause)

29
Q

RL step in gluconeogenesis

A

Fructose-1,6. bisphosphatase

30
Q

Pyridoxal phosphate is derived from what vitamin

A

Vit B 6

31
Q

RL step in cholesterol synthesis

A

HMG-coenzyme A reductase

32
Q

Acetyl CoA carboxylase in involved in

A

RL step in fatty acid synthesis

33
Q

Lecithin-cholesterol acyltransferase in involved in

A

RL step in beta-oxidation of fatty acids

34
Q

AA this is precursor for GABA

A

Glutamate

35
Q

AA Precursor for creatine and NO

A

Arginine

36
Q

AA precursor for histamine

A

Histidine

37
Q

AA precursor for porphyrin and heme

A

Glycine

38
Q

Antibiotics that work at 30S ribosomal subunit

A

Aminoglycosides
(Gentamicin, tobramycin)

and tetracyclines

39
Q

Antibiotics that work at 50S ribsomal subunit

A

Macrolides
(Asithromycin, clarithromycin, erythromycin) Linezolid
Clindamycin
Chloramephenicol

40
Q

Cyanocobalamin

A

Vit B12

Dorsal column dysfunction (loss of vibration sense and proprioception)

Atrophic glossitis
Angular cheilitis

Megaloblastic anemia

41
Q

Folate

A

Vit B9

Megaloblastic anemia
not neurlogic

42
Q

Niacin

A 
Vit B3
Pellagra
Photosensitivity dermatitis
Diarrhea
Neurologic sympmtoms ( encephalopathy, delusions, dementia)
43
Q

Pyridoxine

A

Vit B6

Stomatitis
Glossitis
Cheilitis
Rash

44
Q

Thiamine

A

Vit B1

Beriberi
Wernicke-Korsakoff syn

45
Q

Sclerosis

A

abnormal hardening of body tissue

46
Q

Sclerodactyly

A

thickening and tightening of fingers

47
Q

Telangiectasia

A

Widening of venules
Spider veins
Thread like red lines

48
Q

pruritis

A

itchy

AM- STEP1 (20 decks)

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