Stimulants and ADHD Flashcards Preview

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Flashcards in Stimulants and ADHD Deck (14):
1

Where do stimulants act?

D1 receptors in pre-frontal cortex

2

Where is the abuse potential in stimulants?

Weight loss/appetite suppression

3

ADHD Dx Components

Inattentiveness and hyperactivity

4

Which genes/neurotransmitters are responsible in ADHD?

SR, DA, and NE
Maybe GABA and Ach

5

Anatomical Differences in ADHD

Less DA receptors
Less prefrontal cortex activation and some basal ganglia

6

Ritalin MOA

Blocks reuptake of NE and DA
Reduced distractibility
D>L
High first pass - low bioavail

7

Ritalin Side Effects

Nervousness
Insomnia
Weight loss/loss of appetite
Headache
Tics, seizures, weird heartbeat

8

First use of amphetamines

Decongestant

9

Amphetamines

Dextroamphetamine
Amphetamine salts
Vyvanse - prodrug of amphetamine converted after GI tract

10

Amphetamine vs Ritalin MOA

Amph - blocks DA uptake into vesicles/releases DA into cytoplasm - dump DA into synapse
Ritalin - Blocks DAT and reuptake

11

Ritalin vs Cocaine

Both block DAT, but Ritalin has slower clearance and onset is longer
Normal doses - act in prefrontal cortex, not nucleus accumbens (like cocaine)

12

Effects on NE

Suppression of NE neurons in locus coeruleus (midbrain)

13

2nd line ADHD

NDRI - bupropion
NRI - Strattera - adult approved - 3-6w onset
TCAs
Haldol

14

Alpha 2 agonists

More consistent firing of these neurons from locus coeruleus to prefrontal cortex may = better arousal/attention