Flashcards in Therapeutics of MDD Deck (13):
After 5 days (steady state)
Get trough 12 hours after first dose
Which SSRIs do we want to avoid in elderly and WHY?
Fluoxetine and fluvoxamine
Longest half lives
Who is the dirty SSRI and WHY?
Highest anticholinergic and antihistaminergic side effects
Greatest weight gain
What are the SSRI drug interactions and who has the least/most?
Citalopram and escitalopram have the least
Fluvoxamine has the most
Which SSRI has the greatest risk of QTc prolongation?
Which SNRI has the least drug interactions?
First Line Treatment Options (Pharma)
SSRIs, SNRIs, Remeron, Bupropion
Treatment Resistant: Next Steps
Switch (same or different class)
Add another antidepressant
Add augmentation med
SGAs (Abilify and Seroquel XR)
What is crucial about MAOi and serotonin syndrome?
Happens for sure if you don't allow for a washout period
D/c med for 2 weeks before switching
Flu-like prodrome 1-2 days after stopping and lasting about 1-2 weeks!