SUD

Question 1

how does disulfuram work

Answer 1

blocks aldehyde dehydrogenase which causes build up acetalydehyde

Question 2

what order elimination does alcohol follow

Answer 2

zero order

Question 3

when should you avoid using naltrexone

Answer 3

hepatitis or liver failure

Question 4

when should you avoid using acamprosate

Answer 4

renal disease (but not in kidney stones)

Question 5

which two AD are effective in smoking cessation

Answer 5

1. bupropion 2. nortriptyline

Question 6

which two smoking cessation meds have black box SI warnings

Answer 6

1. bupropion. 2. vareniciline

Question 7

most associated physical finding with PCP intoxication

Answer 7

nystagmus

Question 8

how many drinks can a woman have in a week

Answer 8

10 servings with no more than 2 in one sitting

Question 9

how many drinks can a man have in a week

Answer 9

15 servings with no more than 3 in one sitting

Question 10

pt with vertical or horizontal nystagmus, two most likely illicit drugs did he take

Answer 10

PCP or inhalants

Question 11

what is the period of time to classify someone as being in early remission from etoh

Answer 11

3 to <12 mo

Question 12

what is the period of time to classify someone as being in sustained remission from etoh

Answer 12

12 mo+

Question 13

which enzyme does disulfiram block?

Answer 13

aldehyde dehydrogenase

Question 14

which lab test is the most sensitive indicator of alcoholism

Answer 14

CDT

Question 15

facial dyskinesias indicate which illicit drug use

Answer 15

stimulants (amphetamines) or L-dopa (but with this they would have a clear sensorium)

Question 16

only efficacious tx for cocaine d/o

Answer 16

relapse preventions

Question 17

neurotransmitter involved in opioid withdrawal

Answer 17

norepienphrine

Question 18

cocaine’s MOA

Answer 18

Da reuptake inhibitor

Question 19

best long acting opioid med in pregnant women abusing opioids

Answer 19

methadone

Question 20

what is the weekly drinking limit for women

Answer 20

10/week

Question 21

what is the weekly drinking limit for men

Answer 21

15/week

Question 22

during which period in cocaine w/d does one experience least cravings

Answer 22

hyperphagia (late crash period)

Question 23

MOA of amphetamines

Answer 23

stimulates DA release

Question 24

what is the least lethal route of cocaine intake?

Answer 24

inhaling

Question 25

generally in illicit drug use does one become hyper or hyporeflexive

Answer 25

hypo

Question 26

how long do cocaine metabolites last in the body

Answer 26

96h

Question 27

best tx for alcoholic hallucinosis

Answer 27

benzos

Question 28

during alcoholic hallucinosis is there a clear sensorium

Answer 28

yes

Question 29

which two meds may help with cocaine w/d

Answer 29

1. bromocriptine. 2. amtadine (both dopaminergic)

Question 30

what is the timeline of alcohol w/d

Answer 30

1. w/z sz peak at 1 day 2. hallucinosis peaks at 2 days 3. DT peak at 4-5 days after last drink

Question 31

which neurotransmitter is involved in etoh w/d

Answer 31

glutamate

Question 32

which receptor does glutamate inhibit

Answer 32

NMDA

Question 33

MOA of varenicicline

Answer 33

partial agonist of A4B2 nicotinic receptor

Question 34

severe depression follows use of which drug

Answer 34

MDMA (ecstasy)

Question 35

which neurotransmitter is responsible for relapse

Answer 35

glutamate triggers reward system

Question 36

which pathway is thought to be responsible for addiction

Answer 36

release fo DA from the VTA to the nucleus accumbens.

Question 37

according to the ECA study what are the top two most prevalent disorders

Answer 37

1. SUD 2. Anxiety

Question 38

what is a "field" study

Answer 38

something done to see if it can be used practically