Sulfonamides

Question 1

Sulfonamides

Answer 1

Sulfamethoxazole
Sulfisoxazole
Sulfacetamide
Sulfadiazine

Question 2

MOA sulfonamides

Answer 2

inhibitors of dihydropteroate synthase which mammals lack

Question 3

Are sulfonamides bactericidal or static

Answer 3

Bacteriostatic

Question 4

What are sulfamethoxazole and sulfisoxazole used for

Answer 4

uncomplicated UTIs caused by susceptible organisms

Question 5

What is sulfamethoxazole commonly used in combo with

Answer 5

trimethoprim

Question 6

What is sulfadiazine used for

Answer 6

silver sulfadiazine for topical treatment of burn infections and skin infections

Question 7

Sulfacetamide use

Answer 7

ophthalmic ointment and drops for blepharitis, conjunctivitis, and trachoma

Question 8

Main ADE sulfonamides

Answer 8

Skin rash –> Stevens_johnson syndrome
Crystalluria
Hemolytic anemia in patients with G6PD deficiency
Jaundice –> kernicterus in neonates

Question 9

Contraindications of sulfonamides

Answer 9

Newborn infants due to danger of kernicterus
Do not use in late stages of pregnancy