Sympathomimmetics and Adrenergic Antagonists

Question 0

Direct-acting nonselective sympathomimmetic used for neurogenic shock and LAST RESORT for cardiogenic shock

Answer 0

Norepinephrine

SE: extreme vasospasm, tissue necrosis, arrhythmia, REFLEX BRADYCARDIA

Question 1

Direct-acting nonselective sympathomimmetic used as TOC for cardiac arrest, anaphylaxis, asthma, COPD and hemostasis

Answer 1

Epinephrine

Question 2

Direct-acting nonselective sympathomimmetic used for cardiogenic shock and heart failure

Answer 2

Dopamine

SE: CVS disturbance, arrhythmias

Question 3

Dose-dependent actions of Dopamine

Answer 3

Low-dose: 1-5 mcg/kg/min - increased UO due to increased renal blood flow -> D1 receptor

Medium-dose: 5-15 mcg/kg/min - inc renal blood flow, HR, cardiac contractility and CO via BETA 1

High-dose: >15 mcg/kg/min - vasoconstriction and inc BP via ALPHA rec.

Question 4

Beta nonselective sympathomimmetic used for asthma

Answer 4

Isoproterenol

Question 5

Selective Alpha1 agonist used as decongestant, drug-induced hypotension and spinal shock
SE: REBOUND HYPERTENSION

Answer 5

Phenylephrine
SimD: Pseudoephedrine

Unlike Atropine, it causes mydriasis w/o cycloplegia

Question 6

Alpha2 selective sympathomimmetic antihyoertensive drug known to cause REBOUND HYPERTENSION

Answer 6

Clonidine

Treat REBOUND HPN with Phentolamine

Question 7

Alpha2 selective sympathomimmetic used as TOC for preeclampsia

Answer 7

Methyldopa

SE: hemolytic anemia with positive Coomb’s test

Question 8

Alpha2 selective sympathomimmetic used for glaucoma

Answer 8

Apraclonidine

SimD: Brimonidine

Question 9

Beta1 selective sympathomimmetic used as TOC for acute HF and cardiogenic shock

Answer 9

Dobutamine

Used in cardiac stress testing

Question 10

Beta2 selective sympathomimmetic used as TOC for acute asthma attacks

Answer 10

Albuterol/Salbutamol

May precititate arrhythmias in px wd concurrent COPD and heart dse

Question 11

Beta2 selective sympathomimmetic used as TOC for preterm labor

Answer 11

Terbutaline and Ritodrine

Question 12

Alpha nonselective adrenergic antagonist used as presurgical TOC for Pheochromocytoma

Forming covalent bond with Alpha receptors

Answer 12

Phenoxybenzamine

SE: Orthostatic hypotension, reflex tachycardia

Question 13

Alpha nonselective adrenergic antagonist used as antidote to a1 agonist overdose, REBOUND HYPERTENSION and as presurgical Tx for Pheochromocytoma

Answer 13

Phentolamine

SE: Orthostatic hypotension, reflex tachy

Question 14

A1 selective adrenergic antagonist used as TOC for BPH

Answer 14

Prazosin

SimD: Doxazosin, TERAZOSIN, TAMSULOSIN, Silodosin

Question 15

A1 selective adrenergic antagonist used as Tx for BPH which is the most SELECTIVE to prostate smooth muscle

Answer 15

Tamsulosin

Question 16

Pharmacologic advantage of alpha1 selectivity

Answer 16

Reflex tachycardia is less common and less severe

Question 17

Beta nonselective sympathomimmetic/agonist which sounds like a Beta blocker

Answer 17

Isoproterenol

I SOrry! Akala ko Beta blocker ka!

Question 18

Beta nonselective adrenergic antagonist used as TOC for angina prophylaxis and hypertension

Answer 18

Propanolol

SimD: pindolol, timolol, labetalol, carvedilol

Question 19

Beta nonselective adrenergic antagonist that can be used on hypertensive asthmatic patients bec it is less likely to cause bronchospasm

Intrinsic Sympathomimmetic Activity

Answer 19

Pindolol

Beta1 selective adrenergic antagonist:
Acetabulol

ISA PA! Isa pang chicken joy!
Int. Sympatho. Act. Pindolol Acetabulol

Question 20

Beta nonselective adrenergic antagonist that has a combined alpha and beta blockade

Answer 20

Carvedilol and LABetalol

Question 21

Beta nonselective adrenergic antagonist that is useful in glaucoma patients bec unlike other beta blockers, they lack local anesthetic activity

Answer 21

Timolol

Beta1 selective adrenergic antagonist:
Betaxolol

Question 22

Beta nonselective adrenergic antagonist that has the longest half-life

Answer 22

NADOlol

NAsa DOlo

Question 23

Beta1 selective adrenergic antagonist used for angina, HPN, HF and SVT withless chance of bronchospasm

Answer 23

Atenolol
SimD: Betaxolol, Esmolol, Acetabulol, Metoprolol

SVT: Esmolol ONLY

Question 24

Beta1 selective adrenergic antagonist used for SVT

Answer 24

Esmolol

Question 25

Beta1 selective adrenergic antagonist witthe shortest half-life

Answer 25

Esmolol

Question 26

Carbonic anhydrase inhibitor commonly used for glaucoma

Answer 26

Acetazolamide MOA: dec secretion of aqueous humor from the ciliary epithelium

Question 27

Target BP for antihypertensive patients

Answer 27

No comorbids <130/80

Question 28

Thiazide diuretic used as TOC/first line Tx for Stage 1 hypertension Acts on DCT

Answer 28

Hydrochlorothiazide SimD: Chlorthalidone, Indapamide, Metolazone SE: hypokalemic metabolic alkalosis, dilutional hyponatremia, potassium wasting, hyperglycemia, hyperlipidemia, hyperuricemia

Question 29

Loop diuretic used for HF, pulmonary edema, HPN and ARF Acts on THICK ASCENDING LIMB OF LOOP OF HENLE

Answer 29

Furosemide SimD: Bumetanide, Torsemide, Ethacrynic acid Low Ca, Low Mg

Question 30

Time it takes for Furosemide to take effect, expect UO

Answer 30

6 hours | Brand Name: LaSIX

Question 31

CNS sympathetic outflow blocker used for hypertension with known AE of REBOUND HYPERTENSION

Answer 31

Clonidine Treat REBOUND HPN with Phentolamine

Question 32

Alpha2 selective sympathomimmetic and CNS sympathetic outflow blocker used as TOC for preeclampsia

Answer 32

Methyldopa SE: hemolytic anemia with positive Coomb's test