Synaptic Transmission: Targets of Drug Action

Question 1

Metyrosine

Answer 1

competitive inhibition of tyrosine hydroxylase

Question 2

Reserpine

Answer 2

inhibits VMAT uptake of monoamines into vesicles

Question 3

Bretylium

Answer 3

inhibit action potential generation and calcium dependent synaptic vesicle fusion

Question 4

Cocaine

Answer 4

blocks monoamine reuptake

Question 5

Amphetamine or Ephedrine

Answer 5

reverse monoamine reuptake transporters

Question 6

Naloxone, Naltrexone

Answer 6

Non-peptide blockers of opioid receptors in CNS

Question 7

SSRIs

Answer 7

Selective inhibition of serotonin reuptake transporter

Question 8

ACE inhibitors, eg. lisinopril

Answer 8

Inhibits peptide cleavage of angiotensin I to angiotensin II

Question 9

Phenylephrine

Answer 9

direct agonist of adrenergic receptor

Question 10

MAO Inhibitors

Answer 10

blockade of cytoplasmic metabolism of monoamines

Question 11

L-DOPA

Answer 11

precursor of dopamine, stimulates dopamine production

Question 12

Carbidopa

Answer 12

Blocks L-DOPA conversion to dopamine, does not cross BBB, so protects peripheral adrenergic neurons from producing too much dopamine and NE

Question 13

Tyramine

Answer 13

ingested in diet; competes with NE for transport into synaptic vesicle