systemic mycoses

Question 1

Any opportunistics fungal agent has the capacity to disseminate to sites

Answer 1

systemic mycoses

Question 2

systemic mycoces generally shows ___

22C - fungi
____ - yeast

Answer 2

dimorphism

22C - fungi
35-37C - yeast

Question 3

most prevalent in middle-aged men

as are other systemic mycoses, presumably because occupational and recreational exposure to soil is often greater among men

Answer 3

blastomyces dermatitidis

Question 4

may exhibit flulike symptoms but most often are
asymptomatic

It occurs primarily in North America and parts of Africa.

Answer 4

blastomyces dermatitidis

Question 5

blastomyces dermatitidis was also known as _____

Answer 5

• Gilchrist disease
• North American blastomycosis
• Chicago disease

Question 6

identify the agent!

• Slow to moderate growth
• White to dark tan
• Young colonies tenacious, older colonies glabrous to woolly

Answer 6

B. dermatitidis at 22C mold form

Question 7

microscopic morphology: Oval, pyriform to globose smooth conidia borne on short, lateral hyphalike conidiophores

identify the agent

Answer 7

B. dermatitidis (mold form)

Question 8

culture media and temp for B. dermatitidis yeast form

Answer 8

Blood agar 37C

Question 9

• Large yeast (8-12 um)
• Blastoconidia attached
  by broad base

identify the agent!

Answer 9

B. dermatitidis (yeast)

Question 10

acquired by the inhalation of the microconidia.

microconidia are phagocytized by macrophages in the pulmonary parenchyma

Answer 10

histoplasma capsulatum

Question 11

Usually asymptomatic in intact immune defenses

Calcification may appear in the lungs, liver, and spleen

Answer 11

histoplasma capsulatum

Question 12

diseases of H. capsulatum

Answer 12

• histoplasmosis
• reticuloendothelial cytomycosis
• cave disease
• spelunker’s disease
• darling disease

Question 13

This organism resides in soil with a high nitrogen content, particularly in areas heavily contaminated with bat and bird guano

Answer 13

H. capsulatum

Question 14

enzyme immune assay for H. capsulatum can be performed on:

Answer 14

serum, urine, CSF

Question 15

macroscopic morphology: Slow growth, White to dark tan with age

Wholly, cottony, or granular

Answer 15

H. capsulatum (mold)

Question 16

Tuberculated macroconidia large, round (7- 12 um)

Answer 16

H. capsulatum (mold)

Question 17

Microconidia small, one- celled, round, smooth (2-5 um)

Hyphalike conidiophores

Answer 17

H. capsulatum (mold)

Question 18

culture media and temp of H. capsulatum (yeast form)

Answer 18

• Pines medium
• Glucose-cysteine blood
• BHI agar

37C

Question 19

Small, oval, yeast (2-5 um)

Answer 19

yeast form of H. capsulatum

Question 20

Formation of ulcerative granulomatous lesions of the buccal, nasal, and occasionally gastrointestinal mucosa

Answer 20

Paracoccidioides Brasiliensis

Question 21

Paracoccidioides Brasiliensis primary route

Answer 21

pulmonary

Question 22

narrow range of temp tolerance often likes cooler areas of the body

Answer 22

Paracoccidioides Brasiliensis

Question 23

diseases of Paracoccidioides Brasiliensis

Answer 23

• Paracoccidioidomycosis
• Lutz-Splendore-Almeida disease

Question 24

IDENTIFY!

• Slow growth
• White to beige
• Colony glabrous, leathery, flat to wrinkled, foled or velvety

Answer 24

P. brasiliensis (mold)

Question 25

Colonies frequently only produce sterile hyphae Fresh isolates may produce conidia similar to those of B dermatitidis IDENTIFY!

Answer 25

P. brasiliensis

Question 26

culture media and temp for P. brasiliensis

Answer 26

- BHI agar blood - 37C

Question 27

Multiple blastoconidia budding from single, large yeast (15-30 um)

Answer 27

P. brasilienses (yeast)

Question 28

**most virulent** of all human mycotic agents inhalation of only a few arthroconidia produces primary coccidioidomycosis (pulmonary disease)

Answer 28

Coccidiodes spp.

Question 29

symptom of Coccidiodes may present as allergic manifestation such as __

Answer 29

- toxic erythema - erythema nodosum - erythema multiforme - arthritis

Question 30

desert bumps

Answer 30

erythema nodosum

Question 31

erythema multiforme

Answer 31

valley fever

Question 32

desert rheumatism

Answer 32

arthritis

Question 33

Filipinos and blacks run the highest risk of dissemination of this spp.

Answer 33

Coccidiodes spp.,

Question 34

respiratory symptoms of Coccidiodes

Answer 34

- fever - respiratory distress - cough - anorexia - headache - malaise - myalgia can be present for **6 weeks or longer**

Question 35

Secondary coccidioidomycosis include ___

Answer 35

nodules, cavitary lung disease, and/or progressive pulmonary disease

Question 36

can be converted to the spherule phase in modified converse medium at 40C in 5% to 10% carbon dioxide

Answer 36

C. immitis

Question 37

Alternating one- celled “barrel- shaped” arthroconidia with disjunction cell

Answer 37

C. immitis and C. posadasii

Question 38

Young colonies tenacious, older colonies cottony

Answer 38

C. immitis and C. posadasii

Question 39

identify the agent! - Tend to grow in concentric rings - Rapid growth - White to tan to dark gray

Answer 39

C. immitis and C. posadasii

Question 40

usually seen in endemic region of Southeast Asia infections are usually disseminated, with multiple organ development, this can be typically fatal

Answer 40

Talaromyces Marneffei

Question 41

Talaromyces Marneffei appears as?

Answer 41

cutaneous lesions

Question 42

yeast form of Talaromyces Marneffei can be seen in?

Answer 42

wright stained smears

Question 43

specimen for Talaromyces Marneffei

Answer 43

- **skin lesions** ~ ideal - biopsy specimens

Question 44

may resemble of h. capsulatum, oval to cylindric measuring 3-6 um long

Answer 44

T. marneffei

Question 45

Produces red dffusible pigment

Answer 45

T. marneffei

Question 46

color of vegetative hyphae of T. marneffei

Answer 46

reddish-brown

Question 47

color of arial hyphae of T. marneffei

Answer 47

sparse green