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S2.5 Dermatology > Systemic Presentations > Flashcards

Flashcards in Systemic Presentations Deck (14)
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1
Q

What dermatological presentations are almost always due to cancer?

A
Carcinoid syndrome
Paraneoplastic pemphigus
Erythema gyratum repens
Acquired trichosis lanuginosa
Leser-trelat
Bazex syndrome
Ectopic ACTH syndrome
Paget's/Extra-mammary Paget's
2
Q

How does carcinoid syndrome present? What cancers can cause it?

A

Episodic flushing without sweat
Facial telangiectasia

Can be GI carcinoid (liver mets)
Bronchial, ovarian

3
Q

How does paraneoplastic pemphigus present and what cancer can cause it?

A

Erosive stomatitis
Rash

Non-hodgkins
Castleman’s

4
Q

How does erythema gyratum present and what cancer can cause it?

A

Concentric erythematous lesions

Variable sites and cancers

5
Q

How does acquired trichosis lanuginosa present and what cancer can cause it?

A

Acute onset of lanugo hairs on face and body

Colorectal
Lung, breast, usually advanced

6
Q

What is Leser-Trelat and what cancer can it signify?

A

Eruptive seborrheic keratoses

GI adenocarcinomas

7
Q

What is Bazex syndrome and what can cause it?

A

Hyperkeratosis of extremities
Resembles psoriasis
Non-specific effects on skin biopsy

SCC - bronchial, oropharyngeal, GI
Gastric, colon, biliary adenocarcinomas

8
Q

How does Ectopic ACTH syndrome present?

A

Generalised hyperpigmentation

ACTH > Increased MSH > increased release of melanin from melanocytes

9
Q

How does Paget’s present?

A

Eczematous plaque at nipple/areola

Extension of underlying ductal adenocarcinoma

10
Q

How does extra-mammary paget’s present?

A

Primary intraepithelial adenocarcinoma

Secondary to underlying visceral tumour (bladder, colon)

11
Q

What conditions are strongly associated with cancer but not necessarily universal?

A

Acanthosis nigricans

Dermatomyositis

12
Q

What is dermatomyositis?

A
Inflammatory and rash
Periorbital heliotrope rash
Gottron's papules - red maculo-papular over bony prominences
Shawl sign
Photosensitive poikiloderma
Scalp erythema
13
Q

What skin conditions may be associated with cancer but have no strong link?

A
Bullous pemphigoid
Sweets syndrome
Pyoderma gangrenosum
Acquired ichthyosis
Acquired angioedema
Primary systemic amyloid
Cryoglobulinaemia
14
Q

What are some genetic tumour syndromes with dermatological signs?

A

Peutz-Jeghers - melanosis, colon hamartomas, colon cancer
Muir-Torre - sebaceous tumours, keratoacanthomas - GI/breast/GU cancers
Neurofibromatosis - cafe au lait, ax freckles, neurofibromas, nerve sheath - phaeochromocytoma, carcinoid
MEN syndromes - angiofibromas, neuromas, lichen or macular amyloid, endocrine presentation
Xeroderma pigmentosum - inability to repair sun damage, sarcoma, leukaemia, GI, lung cancer
Howel-Evans - palmaplantar keratoderma, oesophageal