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S2.5 Dermatology > Systemic Presentations > Flashcards

Flashcards in Systemic Presentations Deck (14):
1

What dermatological presentations are almost always due to cancer?

Carcinoid syndrome
Paraneoplastic pemphigus
Erythema gyratum repens
Acquired trichosis lanuginosa
Leser-trelat
Bazex syndrome
Ectopic ACTH syndrome
Paget's/Extra-mammary Paget's

2

How does carcinoid syndrome present? What cancers can cause it?

Episodic flushing without sweat
Facial telangiectasia

Can be GI carcinoid (liver mets)
Bronchial, ovarian

3

How does paraneoplastic pemphigus present and what cancer can cause it?

Erosive stomatitis
Rash

Non-hodgkins
Castleman's

4

How does erythema gyratum present and what cancer can cause it?

Concentric erythematous lesions

Variable sites and cancers

5

How does acquired trichosis lanuginosa present and what cancer can cause it?

Acute onset of lanugo hairs on face and body

Colorectal
Lung, breast, usually advanced

6

What is Leser-Trelat and what cancer can it signify?

Eruptive seborrheic keratoses

GI adenocarcinomas

7

What is Bazex syndrome and what can cause it?

Hyperkeratosis of extremities
Resembles psoriasis
Non-specific effects on skin biopsy

SCC - bronchial, oropharyngeal, GI
Gastric, colon, biliary adenocarcinomas

8

How does Ectopic ACTH syndrome present?

Generalised hyperpigmentation
ACTH > Increased MSH > increased release of melanin from melanocytes

9

How does Paget's present?

Eczematous plaque at nipple/areola
Extension of underlying ductal adenocarcinoma

10

How does extra-mammary paget's present?

Primary intraepithelial adenocarcinoma
Secondary to underlying visceral tumour (bladder, colon)

11

What conditions are strongly associated with cancer but not necessarily universal?

Acanthosis nigricans
Dermatomyositis

12

What is dermatomyositis?

Inflammatory and rash
Periorbital heliotrope rash
Gottron's papules - red maculo-papular over bony prominences
Shawl sign
Photosensitive poikiloderma
Scalp erythema

13

What skin conditions may be associated with cancer but have no strong link?

Bullous pemphigoid
Sweets syndrome
Pyoderma gangrenosum
Acquired ichthyosis
Acquired angioedema
Primary systemic amyloid
Cryoglobulinaemia

14

What are some genetic tumour syndromes with dermatological signs?

Peutz-Jeghers - melanosis, colon hamartomas, colon cancer
Muir-Torre - sebaceous tumours, keratoacanthomas - GI/breast/GU cancers
Neurofibromatosis - cafe au lait, ax freckles, neurofibromas, nerve sheath - phaeochromocytoma, carcinoid
MEN syndromes - angiofibromas, neuromas, lichen or macular amyloid, endocrine presentation
Xeroderma pigmentosum - inability to repair sun damage, sarcoma, leukaemia, GI, lung cancer
Howel-Evans - palmaplantar keratoderma, oesophageal