Flashcards in Systemic Presentations Deck (14):
What dermatological presentations are almost always due to cancer?
Erythema gyratum repens
Acquired trichosis lanuginosa
Ectopic ACTH syndrome
How does carcinoid syndrome present? What cancers can cause it?
Episodic flushing without sweat
Can be GI carcinoid (liver mets)
How does paraneoplastic pemphigus present and what cancer can cause it?
How does erythema gyratum present and what cancer can cause it?
Concentric erythematous lesions
Variable sites and cancers
How does acquired trichosis lanuginosa present and what cancer can cause it?
Acute onset of lanugo hairs on face and body
Lung, breast, usually advanced
What is Leser-Trelat and what cancer can it signify?
Eruptive seborrheic keratoses
What is Bazex syndrome and what can cause it?
Hyperkeratosis of extremities
Non-specific effects on skin biopsy
SCC - bronchial, oropharyngeal, GI
Gastric, colon, biliary adenocarcinomas
How does Ectopic ACTH syndrome present?
ACTH > Increased MSH > increased release of melanin from melanocytes
How does Paget's present?
Eczematous plaque at nipple/areola
Extension of underlying ductal adenocarcinoma
How does extra-mammary paget's present?
Primary intraepithelial adenocarcinoma
Secondary to underlying visceral tumour (bladder, colon)
What conditions are strongly associated with cancer but not necessarily universal?
What is dermatomyositis?
Inflammatory and rash
Periorbital heliotrope rash
Gottron's papules - red maculo-papular over bony prominences
What skin conditions may be associated with cancer but have no strong link?
Primary systemic amyloid