T-1B-B-The Extracellular Matrix

Question 1

This surrounds the body tissues

Answer 1

Extracellular matrix

Question 2

other name for body tissues

Answer 2

connective tissues

Question 3

few things ecm does

Answer 3

1. guides cells
2. networks cells
3. relays signals

Question 4

3 impotance of ecm

Answer 4

1. elasticity
2. protection
3. involvement of processes

Question 5

3 classes of biomolecules

Answer 5

1. structural proteins
2. specialized proteins
3. proteoglycans

Question 6

most abundant protein in the animal world. has 19 types.

Answer 6

Collagen

Question 7

how many residue does collagen have

Answer 7

3.3 residue (triple helix)

Question 8

smallest amino acid

Answer 8

glycine

Question 9

how many types of collagens are there

Answer 9

5 types

Question 10

Type I collagen

Answer 10

bone, skin, dentin, blood vessels, fibrocartilage, and tendon

Question 11

Type II collagen

Answer 11

Cartilaginous tissue

Question 12

Tyype III

Answer 12

Skin, ligaments, blood vessels, and internal organs

Question 13

Type IV

Answer 13

basement membrane of various tissues

Question 14

Tpe V

Answer 14

Blood vessel wall, synovium, corneal stroma, tendon, lung, bone, and skletal muscle

Question 15

proline turns to hydoxyproline because of this acid

Answer 15

ascorbic acid

Question 16

important factor in determining strength of collagen

Answer 16

hydroxylation of proline

Question 17

what is triggers lysine residue to hyroxylysine

Answer 17

oxidative deamination with copper

Question 18

Ehlers- Danlos syndrome

Answer 18

hyperextensibility of the skin, abnormal tissue, fragile. type IV and VI effected

Question 19

Epidermolysis bullosa

Answer 19

skind breaks due to minor trauma. type VII effected

Question 20

Scurvy

Answer 20

ascorbic acid deficiency

Question 21

the primary sequence for collagen protein synthesis is coded in

Answer 21

DNA

Question 22

no hydroxylysine
no triple helix
no repeating structure
no carbohydrate

Answer 22

Elastin

Question 23

has intramolecular aldon cross links

Answer 23

collagen

Question 24

is fibronectin involved in the migration of cells? T or F

Answer 24

True. it is involved in the migration of cells

Question 25

what does the glomular filtrate

Answer 25

urine

Question 26

fluid that filters through glomeruli into bowmans capsule

Answer 26

Glomerular filtrate

Question 27

are amino acids and plasma proteins excreted into the urine?

Answer 27

no. amino acids and plasma are reabsorbed

Question 28

what is the normal value of glomerular filtrate rate

Answer 28

125ml/min or 180 liter/day

Question 29

leakage of proteins in the urine

Answer 29

glomerulonephritis

Question 30

this is a glycoaminoglycans connected to a core protein molecule

Answer 30

Proteoglycans

Question 31

Can proteoglycans hold large amount of water? | T or F

Answer 31

True

Question 32

composed of type I collagen with Type V collagen in small amounts

Answer 32

Bones

Question 33

major cells involved in the bone resorption and deposition

Answer 33

osteoclasts and osteblats

Question 34

for bone resorption

Answer 34

osteclasts

Question 35

for bone deposition

Answer 35

osteoblasts

Question 36

descendants of osteoblats and help in bone matrix

Answer 36

osteocytes

Question 37

Osteopetrosis

Answer 37

marble bone disease - inability to resorb

Question 38

osteoporosis

Answer 38

imbalance in reorption and deposition

Question 39

osteogenesis imperfecta

Answer 39

brittle bones - sclere of eye is thin

Question 40

rickets

Answer 40

bones lack to calcify | due to lack of calcium

Question 41

major proteoglycan in cartilage is

Answer 41

aggrecan

Question 42

major collagen component in cartilage

Answer 42

Collagen type II

Question 43

3 types of cartilages

Answer 43

Hyaline Elastic fibroelastic

Question 44

Chondroplasia

Answer 44

hereditary. short limb dwarfism due to failure of devlp. cartilages

Question 45

ECM is also important in producing cancer cells T or F

Answer 45

True

Question 46

normal joints have this fluid

Answer 46

synovial fluid

Question 47

arthritis have synovial fluid T or F

Answer 47

False