T Cell Development

Question 1

where T cells become MHC restricted and lineage committed

Answer 1

thymus

Question 2

where T cells are tolerized to self antigens

Answer 2

thymus

Question 3

CD8 binds MHC Class ___

Answer 3

I

Question 4

CD4 binds MHC Class ___

Answer 4

II

Question 5

site of TCR gene rearrangements

Answer 5

thymus

Question 6

Hassall’s corpuscles and dendritic cells are found in the

Answer 6

thymus

Question 7

T-cell precursors originate in

Answer 7

bone marrow

Question 8

mature T cells migrate from thymus to

Answer 8

secondary lymphoid tissues

Question 9

what are prothymocytes and from what are they formed?

Answer 9

• T cell precursors

- fetal liver and bone marrow

Question 10

thymic anlage produces

Answer 10

chemotactic factors - attract T cell progenitors

Question 11

prothymocytes enter thymus at

Answer 11

cortico-medullary junction via blood vessels

Question 12

chemokines and sphingosine 1-phosphate receptors

Answer 12

control migration of thymocyes

Question 13

mature thymocytes (+ selection) leave thymus through

Answer 13

venules in medulla

Question 14

which chain gets rearranged first in TCR development

Answer 14

Beta

Question 15

a common double-negative T cell progenitor gives rise to

Answer 15

alpha:beta and delta:gamma cells

Question 16

rearrangement of TCR alpha-chain gene eliminates

Answer 16

linked delta-chain locus

Question 17

where does negative selection of thymocytes occur? What cell components are involved?

Answer 17

• thymus

- dendritic cells, macrophages

Question 18

what role does avidity play in T cell selection

Answer 18

determines strength of signal delivered - want sweet spot

Question 19

what interacts with the same antigen presenting cell to suppress autoreactive T cells

Answer 19

Treg