T cell immunity definitions Flashcards
1
Q
main APCs for T cells
A
macrophages, dendritic cells, B cells
2
Q
B7 (B7.1 CD80 and B7.2 Cd28)
A
- major T cell co-stim molcules
- bind CD28 on T cells
3
Q
CD28
A
B7 receptor on T cells (B7 is co-stim)
-activation and proliferation of T cells
4
Q
CDLA-4
A
on T cells, high affinity for B7
-shuts off T cell response
5
Q
serine proteases in cytotoxic T cells; induce apoptosis in target cells
A
grazymes
6
Q
cytokine; produced by activated naive T cells; essential for further proliferation and differentiation
-role in contraction of adaptive immune response
A
IL-2
7
Q
hematopoietic GF secreted by stromal cells in bone marrow and thymus; T cell development, survival, homeostasis
A
IL-7
8
Q
perforin
A
can form membrane pores - killing mechanism of cell-mediated cytotoxicity
