T Cells Flashcards
1
Q
TH1, TH2, and TH17, are all what?
A
CD4+ effector T cells! (Lymphocytes, they come from lymphoid organs)
2
Q
How does TH17 come about?
A
In response to extracellular bacteria, fungi. Cytokines produced: IL-17a, IL-17b, IL-22.
(IL-23 helps carry on/ boost production - costimulation)
3
Q
What are the cytokines produced by Thelper17 cells, and what do they do?
A
IL17 (a,b), IL22.
IL-17, pop to tissue cells and make chemokines molecules (eg recruit more innate cells like neutrophils to the site of infections
+ help produce anti-microbial peptides
IL-22: ‘barrier cytokine’ increases barrier function of epithelium
