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Immunology Week 1 Cards > T Cells > Flashcards

Flashcards in T Cells Deck (11):
1

What part of immunity do T cells participate in?

adaptive, cell mediated immunity

2

How kind of infections do T cells fight against?

mostly intracellular but also some extracellular

3

How do T cells assist in defense against extracellular infections?

recruiting leukocytes that destroy pathogens and by helping B cells make effective antibodies

4

Helper T cell effector function

Activation of macrophages

inflammation

activation and proliferation of T and B lymphocytes

5

Cytotoxic T lymphocyte effector function

killing of infected cell

6

Can T cells interact with free floating antigens?

no

7

Activation of naive T cells requires what?

recognition of peptide-MHC complexes presented on dendritic cells

8

What molecules are required to activate T cells?

MHC-complex on dendritic cells and costimulators

9

CD4 T cells are mediated how?

by cytokines

10

Naive CD4 T cells are activated by antigens: now what?

they secrete Interleukin-2, a growth factor that stimulates the proliferation of (clonal expansion) of the antigen specific T cells

11

activated CD4 T clones can do one of two things, what are they?

1. Some will secrete cytokines and recruit leukocytes and stimulate production of microbicidal substance in phagocytes

others secrete cytokines that help B cells produce a type of antibody called immunoglobulin E (IgE) + activate eosinophils