T1

Question 1

What is the medication involved in hyperplasia of connective tissue is related to gingival hyperplasia?

Answer 1

Phenytoin (dilantin)

Question 2

What is CXCL8?

Answer 2

Chemokine that is secreted by macrophage when it is activated and it recruits other cells - specifically neutrophils!

Question 3

What is IL-12?

Answer 3

Recruits and activates NK cells; secreted from activated macrophage

Question 4

What are the pro-inflammatory cytokines?

Answer 4

IL-1, IL-6, IL-12, IL-17
TNF-a
IFN-y
CXCL8

Question 5

What are the anti-inflammatory cytokines?

Answer 5

IL-4, IL-10, IL-22

TGF-b

Question 6

Only cytokine to shut off venous return:

Answer 6

TNF-a

Question 7

nTreg cells are developed in the thymus because they’re bound to:

Answer 7

Hassell’s corpuscles

Question 8

nTreg = \_\_ tolerance
iTreg = \_\_ tolerance

Answer 8

nTreg = thymic tolerance
iTreg = peripheral tolerance

Question 9

Treg cells are regulatory cells that are present to:

Answer 9

suppress other T cells because the immune system might cause too much damage

Question 10

What is the function of CCL18?

Answer 10

Recruit naive T cells to the lymph node to bind to the dendritic cells that have done antigen processing

Question 11

The part of the pathogen to which the antibody binds is the antigenic determinant

Answer 11

Epitope

Question 12

Storage form of iron:

Answer 12

Hemosiderin

Question 13

Dendritic cells can activate T cells because they express:

Answer 13

B7

Question 14

What is the transcription factor that drives Th1 T cell differentiation?

Answer 14

T-Bet

Question 15

What cytokines are used by CD8 T cells to induce apoptosis?

Answer 15

Fas/FasL

Question 16

What cytokine is secreted by DC to recruit naive T cells?

Answer 16

CCL18

Question 17

Variability in the Class 1 = ?

Answer 17

heavy chain

Question 18

Variability in the Class 2 = ?

Answer 18

beta chain

Question 19

Affinity occurs in the ___ side, avidity occurs in the ___ side.

Answer 19

Affinity = cortical
Avidity = medullary

Question 20

T cell activation occurs in the __

Answer 20

paracortex

Question 21

Naive T & B cells come in and out of circulation through:

Answer 21

HEV

Question 22

___ on the T-cell binds to ICAM on the dendritic cells

Answer 22

LFA-1

Question 23

T cell binds to the HLA via phosphorylation, this is the:

Answer 23

critical step

Question 24

CD3 signals cause conformational change in LFA-1, so:

Answer 24

rolling stops

Question 25

CD28 binds to __ on dendritic cells

Answer 25

B7

Question 26

Resting T cell has __

Answer 26

L-selectin

Question 27

L-selectin binds to:

Answer 27

S-Lex on resting epithelium

Question 28

L-selectin becomes:

Answer 28

VLA-4

Question 29

c5a, c3a =

Answer 29

anaphylaxis

Question 30

Hyalinized appearing eosinophilic staining encircling blood vessels is called:

Answer 30

fibrinoid necrosis

Question 31

If you have prolonged GERD that is left untreated, you can get:

Answer 31

Barrett's Metaplasia

Question 32

___ can sometimes be precancerous, such as in the oral cavity.

Answer 32

Hyperplasia

Question 33

Is hydronic swelling reversible?

Answer 33

Yes

Question 34

Apoptosis is regulated by what family proteins?

Answer 34

BCL-2 family and p53 (guardian of genome)