Flashcards in T2-Antiulcer Medications Deck (28):
What are some stomach acid problems?
GERD, heartburn, erosive esophagitis, ulcers
What are the 5 causative factors of stomach acid problems?
H. Pylori (ulcers only)
What nonpharmacologic measures can you teach your client for stomach problems?
-Avoid spicy food and caffeine
-Alcohol may exacerbate symptoms
-Lowering stress and anxiety may cause ulcers to heal quicker
What is the MOA of proton pump inhibitors?
Inhibiting the H-K-ATPase pump so H doesn't go to the stomach, so the stomach doesn't turn more acidic
What is the MOA of H2 receptors?
Blocking the H2 receptor, which activates the H-K-ATPase pump
What is the suffix for proton pump inhibitors?
Are prazoles well tolerated?
What is the adverse effect of prazoles?
When does acid rebound occur?
Mainly when you are taking it chronically and then stop
What can you do to prevent acid rebound?
Taper when stopping
Take an antacid or H2 blocker to help
How long can acid rebound last?
What are some of the CONTROVERSIAL adverse effects to proton pump inhibitors? (4)
Nutritional deficits (b12, iron, magnesium, calcium)
Osteoporosis/fractures (due to the deficits)
When should you take a prazole?
Is it okay to crush a prazole?
BEFORE BREAKFAST; no--they are DR tabs
Why should you take a prazole before breakfast?
The pump has to be on to break it. Food activates the pump. Take the med first so your "warriors" are ready for battle. Eat your food (the enemy that activates the pump). Your warriors are already in your system ready for battle, so they will be there to turn off the pump.
Does prazoles bind reversibly or irreversibly to the pump?
IRREVERSIBLY--pump is permanently broken!
What is the suffix for H2 blockers?
What are the adverse effects of H2 blockers?
-Tolerance (body is going to keep making gastrin to activate the pump since the H2 receptor is blocked)
-Confusion (if levels are too high)
Can you take an antacid with H2 receptor?
No, not at the same time
Why can't you take an antacid with an H2 receptor at the same time?
H2 won't absorb
If you want to take both an antacid and H2 blocker, how far should you space taking the different meds?
Take the H2 first so there is time for it to absorb, THEN ONE HOUR LATER, take your antacid
What is the MOA of sucralfate?
Creates a protective barrier over an ulcer
What does the pH of the stomach have to be for sucralfate to work?
less than 4
Does the stomach need to be slightly acidic or basic for sucralfate to work?
How long does the protective coating of sucralfate work?
____ occurs in 2% of clients who take sucralfate.
Can sucralfate be taken with antacids?
Antacids are _____ that just raise the pH to make it less ____ and more ____. Antacids have to be taken frequently to provide all day relief.
Receptorless; less acidic, more basic