T4-Erectile Dysfunction Flashcards
(22 cards)
How do you get an erection?
Sexual stimulation occurs causing the release of nitric oxide which releases cyclic GMP [muscle relaxation of corpus cavernosum]. The muscle relaxation causes the penis to fill up with blood. ERECTION!
What does PDE5 do?
Causes the erection to subside
People with ED have too much ___ and their erection doesn’t last or never happens–i.e they have ED.
PDE5
What is the type of drug given to people with ED?
PDE-5 Inhibitors
What is the MOA of PDE5 inhibitors?
Cause selective inhibition of PDE5, which increases the preserves cGMP levels in the penis, thereby making the erection harder and more long lasting
T/F: PDE-5 inhibitors only enhance the normal erectile response to sexual stimuli.
TRUE; if there is no sexual stimuli and you are taking a PDE5 inhibitor, nothing will happen
What are 3 ED drugs?
All end in -fil
Slidenafil
Vardenafil
Tadalafil
What are the 3 indications for the -fil?
- ED
- Pulmonary arterial HTN (PAH)
- Benign prostate hypertrophy (BPH)
When should clients take their ED med?
30-60 minutes before sexual activity
Which ED meds are PRN? How long do these effects last?
Slidenafil and vardenafil; 4-6 hours
Which ED med is known as “the weekender” (can also be taken daily) and how long does its effects last?
Tadalafil; 36 hours
What are the adverse effects to ED drugs?
Headache
Flushing
Dyspepsia
Nasal Congestion
What are the RARE adverse effects of ED drugs? (4)
- Hypotension
- Priapism
- Hearing loss
- Vision disturbances
Rare adverse effects: what is priapism?
Erection greater than 4 hours! MUST get to a doc and get penis drained before 6 hours or there will be permanent ED
Rare adverse effects: What happens if a patient has hearing loss?
Reports of sudden hearing loss that is unilateral –this is RARE!!
Rare adverse effects: What happens with vision disturbances?
Blue tinge to the vision
What are the 2 drug interactions that happen with ED drugs?
- Nitrates
2. Alpha blockers
What happens if you take a nitrate and an ED drug?
Nitrates increase cGMP formation and ED drugs decrease cGMP breakdown= SO MUCH cGMP!! This can cause life threatening hypotension; must wait 24 hours or longer before taking a nitrate after taking an ED drug
What nitrates can ED patients not take?
ALL FORMS; Nitroglycerin SL tabs and patches and isosorbide dinitrate!!!!
What are alpha blockers commonly used in? What is their suffix? and what happens if you combine an ED drug with an Alpha Blocker?
BPH; -zosin or -osin; POSTURAL HYPOTENSION
What happens if you take an ED drug with an alpha blocker? Why?
Postural hypotension; hypotension is a rare adverse effect of ED drugs + Alpha blockers dilate arterioles and can LOWR BP
*a normal dose of ED drug may cause the BP to drop by ~8mmHg, if taking with a nitrate or alpha blocker, this will cause a drastic decrease!!
What is the client teaching regarding ED drugs? (3)
- Avoid nitrates
- Go to doc if erection is longer than 4 hours
- Ask about prostate meds (alpha blockers)
