TB chemoprophylaxis

Question 1

What are the 2 forms of TB chemoprophylaxis?

Answer 1

Tuberculosis preventive therapy (TPT)
* Isoniazid preventive therapy (IPT)

Question 2

Before initiating TPT, what should you do?

Answer 2

Rule out TB
TPT should undergo clinical evaluation (symptom check and physical examination - CXR) and be tested with
GeneXpert (Xpert), even if asymptomatic.

Question 3

Who requires TPT? (5)

Answer 3

TB contacts: All adults, adolescents and children (including newborns or
infants) exposed to TB require TPT ,once T.B disease has been excluded through evaluation

People living with HIV: All adults, adolescents and children including infants living with HIV (irrespective of a known significant TB exposure)

Inmates in correctional facilities after ‘significant TB exposure’
* Healthcare workers
* People who previously had TB after ‘significant TB exposure’

Question 4

What is the 3HP chemoprophylaxis regimen?

Answer 4

3 months of weekly isoniazid PLUS rifapentine

Question 5

What is the 3HR chemoprophylaxis regimen?

Answer 5

3 months of daily rifampicin PLUS isoniazid

Question 6

What is the 6H chemoprophylaxis regimen?

Answer 6

6 months of daily isoniazid

Question 7

What is the 12H chemoprophylaxis regimen?

Answer 7

12 months of daily isoniazid

Question 8

Symptoms screening -which symptoms to screen for?

Answer 8

HIV+
* Cough (any duration)
* Fever
* Unexplained weight loss
* Night sweats
* History of previous TB
* Adherence to ART