Tx of LRTI II

Question 1

What are the properties of Baricitinib?

Answer 1

Janus kinase inhibitor that has anti-inflammatory
properties.

Question 2

What are the indications of Baricitinib?

Answer 2

Registered for the treatment of several dermatological conditions and
rheumatoid arthritis.

Question 3

How does Baricitinib treat COVID-19?

Answer 3

It reduces levels
of multiple cytokines associated with the pathophysiology of COVID-19
disease, as well as having anti-viral activity.

Question 4

How do viral vector vaccines work?

Answer 4

Use replication-deficient viruses engineered to express the genetic
sequence of the antigen of interest in host cells.
* Recombinant, replication-incompetent human adenovirus serotype
26 vector encoding a full-length, stabilized SARS-CoV-2 S protein
(Ad26.CoV2.S; Johnson & Johnson)
* Single dose (+ booster after at least 2 months)

Question 5

How do mRNA vaccines work?

Answer 5

Lipid nanoparticles are used to protect the prefusion-stabilized S protein–encoding mRNA en route to the intracellular space.
* The host uses nucleoside-modified mRNA to make the target spike glycoprotein (full length S-protein with proline substitutions), which
induces a coordinated immune response. (Pfizer-BioNTech)

Question 6

How many doses are needed for the covid-19 mRNA vaccines?

Answer 6

2 doses at least 3 weeks apart (+ booster after at least 6 months)

Question 7

How many doses are needed for the Inactivated antigen vaccines

Answer 7

2 doses at least 2-4 weeks apart

Question 8

What are the common side effects of covid vaccines?

Answer 8

Rarely anaphylaxis (within minutes to hours)
* Myocarditis & pericarditis after mRNA vaccination
* Rare form of blood clots (between 4 days and 3 weeks)

Question 9

Vaccine cautions (3)

Answer 9

Thrombocytopenia
* Bleeding disorders
* On coagulation therapy