TB Pharm

Question 1

Isoniazid Mechanism

Answer 1

Interferes with Mycolic acid synthesis. Kills rapidly dividing bacilli, extracellular cavity lesions. Static for slow growing

Question 2

How well does Isoniazid distribute>

Answer 2

Distributes well to all tissues and bodily fluids, with inflamed meninges it can get into CSF

Question 3

Is Isoniazid ever used alone in ACTIVE cases>

Answer 3

Never! Resistance develops quickly. Can be used alone in latent TB however.

Question 4

Main adverse effect of Isoniazid

Answer 4

Peripheral neuropathy Burning in hands and feet as a result of the competition between isoniazid and pyridoxal phosphate. This is corrected by B6 supplements and often affects malnourished, diabetics, and alcoholics mostly

Question 5

Don’t give Isoniazid with

Answer 5

antacids

Question 6

How does Rifampin work?

Answer 6

Binds RNA polymerase

Question 7

Never give Rifampin as a single agent

Answer 7

true

Question 8

How does resistance occur to Rifampin

Answer 8

ALterations in the Beta subunit of RNA polymerase where the Rifampin binds

Question 9

Does Rifampin penetrate the CSF

Answer 9

Yes, along with all other tissues

Question 10

What TB drug discolors body fluids

Answer 10

Rifampin

Question 11

Other Rifampin side-effectsq

Answer 11

GI disturbances and Nervous system complaints

HEPATIC SE: Jaundice occurs in the elderly and alcoholics with chrinic liver disease

Question 12

Ethambutol MOA

Answer 12

disrupts cell wall synthesis,

Question 13

Ethambutol is only active against bacteria that are

Answer 13

rapidly dividing

Question 14

Major Ethambutol SE

Answer 14

Optic neuritis- decreased visual acuity, loss of color discrimination, constriction of visual fields,