TBI Flashcards

(47 cards)

1
Q

define TBI

A

disruption in the normal function of the brain that can be caused by a bump, blow, or jolt to the head or a penetrating head injury

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2
Q

how to assess severity of a TBI

A

glasgow coma score

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3
Q

4 points of eye response in CGS

A

No eye opening
Eye opening to pain
Eye opening to verbal command
Eyes open spontaneously

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4
Q

5 points of verbal response in CGS

A

no response
incomprehensible sounds
inappropriate words
confused
oriented

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5
Q

6 points of motor response in CGS

A

no response
extension to pain
flexion to pain
withdrawal from pain
localizing to pain
obeys commands

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6
Q

what CGS is mild TBI

A

13-15

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7
Q

what CGS is severe TBI

A

3-8

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8
Q

most common cause of TBI is

A

falls

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9
Q

are M or F more likely to experience TBI

A

M

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10
Q

describe mechanisms of primary injury in TBI

A

contact: impact or penetration
sudden acceleration/ decceleration

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11
Q

3 types of injury in TBI

A

focal
diffuse
mixed

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12
Q

what is secondary injury

A

brain cells continue to die after primary injury in min-days following

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13
Q

Intracranial hemorrhage, subarachnoid hemorrhage, subdural hematoma leads to

A

hydrocephalus and vasospasm

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14
Q

systemic hypotension results in

A

decreased perfusion

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15
Q

impaired cerebral vascular autoregulation results in

A

↑BP = ↑ CBF, ↓BP = no perfusion, lacks regular regulation even when BP fluctuates

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16
Q

in TBI there is increased metabolic demand due to

A

seizures, fever, agitation

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17
Q

Free radicals, excitotoxicity, disruption of BBB → _________ → ______

A

cerebral edema

↑ICP

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18
Q

5 predictors of poor outcome from TBI

A

older age
lower CGS score
abnormal pupillary response
systemic hypotension
abnormalities on CT scan

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19
Q

target SBP in TBI

20
Q

target MAP in TBI

21
Q

target O2 sat and PaO2 in TBI

22
Q

how to improve SBP and MAP in TBI

A

fluid resus
vasopressors if fluids fail

23
Q

how to improve O2 sat and PaO2

A

mechanical ventilation

24
Q

surgical interventions for TBI include

A

external ventricular drainage
surgical evacuation of intracranial hematomas
surgical removal of foreign bodies
decompressive craniectomy

25
EVD is to
monitor ICP or control hydrocephalus
26
why is sedation done in TBI
to control agitation + pain and facilitate mech ventilation reduce ICP, brain oxygen consumption
27
propofol onset/ offset time
fast both
28
propofol MOA
GABA-A receptor agonist
29
propofol properties
antiseizure neuroprotective
30
propofol AEs
propofol infusion sx hemodynamic instability respiratory depression
31
anxiolytic in TBI for sedation
midazolam
32
which opioid is used in TBI for sedation
fentanyl
33
target CPP
>60mmHg
34
CPP =
MAP - ICP
35
target ICP
<20mmHg
36
hyperventilation can help control _________ by _________
ICP by causing cerebral vasoconstriction (acute drop in PaCO2 = reflex cosntriction)
37
T or F: hyperventilation in TBI can be used LT to control ICP
F- limits blood flow to brain necessary to heal
38
which hyperosmolar agents are used to decrease ICP in TBI
mannitol and hypertonic saline
39
mannitol SEs
hypotension, ARF
40
mannitol MOA
draws water out of cells decreases blood viscosity resulting in more cerebral blood flow
41
hypertonic saline MOA in TBI
increases osmotic gradient to draw water out of cells to decrease ICP
42
in TBI DVT prophylaxis, _______ is initially used then ____ or ____ if not CI
pneumatics initially LMWH and unfractionated heparin
43
infection prophylaxis in TBI is recommended for
penetrating head trauma
44
a phenobarb coma is done in TBI to _______ and _______
reduce ICP and brain metabolism
45
phenobarbital coma SEs
hypotension, decreased GI motility
46
in pts with medically induced hypothermia to reduce ICP, what is important to watch
drug dosing- all metabolism slows down
47
T or F: high dose corticosteroids is recommended for reducing ICP in TBI
F- increases mortality