Terms to know for Exam II

Question 1

what are IgM antibodies?

Answer 1

the first type of antibody made in response to an infection

Question 2

what are IgE molecules?

Answer 2

allergy response mechanism that binds to mast cells. causes an allergic reaction if enough antigen has bound with the IgE antibodies

Question 3

what are IgG antibodies?

Answer 3

antibodies that protect you against infection by “remembering” which germs you’ve been exposed to before

Question 4

Boys with X-linked agammaglobulinemia have a congenital loss-of-function mutation in
Btk. An acquired gain-of-function mutation in this molecule may contribute to:
A. B-cell lymphoma development.
B. T-cell immunodeficiency.
C. tolerance to transplanted organs.
D. hyper-IgM syndrome.

Answer 4

A

Question 5

Defects in CD40L will cause alterations in concentrations of different Igs. How are the Igs effected?

Answer 5

IgM is elevated while other Ig isotypes are decreased

Question 6

Mechanisms of central T cell tolerance are:
A. Generation of T regulatory cells in the gut
B. Anergy and activation induced cell death after T cells encounter with antigen presenting
cells in peripheral lymph nodes
C. Negative selection and generation of T regulatory cells in thymus
D. Cross-linking of IgD by antigen
E. Interaction between CD22 on B lymphocytes and antigen presenting cell

Answer 6

C