Test 3 - 10/4 Lecture Flashcards
When we are born we have what nACh-R?
fetal/immature
5 subunits of the high conductance nicotinic ACh receptors
Alpha, Alpha-1, Beta-1, Delta, Epsilon
5 subunits of the low conductance nicotinic ACh receptors
Alpha, Alpha-1, Beta-1, Delta, Gamma
Normally ACh receptors should only be found in what zone?
Junctional zone
The part of the post-synaptic neuron surrounding the neuromuscular junction
junctional area
The area just outside of the junctional area on the post-synaptic neuron is called
perijunctional area
The area of the postsynaptic neuron that is furthest from the neuromuscular junction is referred to as
Postjunctional area
When giving a depolarizing agent like succs what area will it affect?
Should be localized to the junctional zone
with paralytics you’re preventing the _____ to be able to talk to the _____
Neuron
muscle
In a denervating injury we would see more immature nicotinic ACh receptors placed at what portion of the post-synaptic membrane.
Postjunctional area
In a healthy muscle we shouldn’t have any nicotinic ACh receptors in the ______
Postjunctional area
Motor neurons are found in _____
nerves
What happens when we place electrodes on top of a nerve and run current through?
Will generate and AP and cause depolarization in the nerve
If we run current through ulnar nerve and we get no twitch that would tell us what?
the block is deep
Electrical current requires one _______ and one _______
cathode and anode
Between the cathode and anode we are circulating
electrons/negative charges
If both the outside of the cell and the inside of the cell are negative then we create _________ resulting in an ________
depolarization; action potential
How do the fast Na channels open when we run electrical current on a nerve?
The current causes depolarization..this will cause the fast Na channels to open (Action Potential)
EKG’s are focused with the current on the _____ of the cell
outside
supramaximal stimulus
Strong enough to recruit all the motor neurons in the underlying nerve. Should give us a nice bit twitch.
Single twitch will show us ______ while TOF would show us _____
one impulse
More than one impulse
TOF response to an incomplete block for non-depolarizing vs a depolarizing
Non depolarizing: not all twitches at same magnitude (B/A ratio)
depolarizing: should be at an equal height for each of the twitches
Train of 4 is a stimulation that occurs
2 Hz/2 Seconds (4 impulses over a timeframe of 2 seconds)
Train of four ratio
Measured when utilizing non-depolarizing muscle relaxants B/A 4th twitch/1st twitch